ArticleJournal of behavioral addictions2025
Exploring the role of the amygdala in Compulsive Sexual Behavior Disorder via a parcellation pipeline based on Recurrence Quantification Analysis.
Article in Journal of behavioral addictions, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
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Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Striato-limbic and frontoparietal dysfunction underlying imbalance of reward-motivation and cognitive control in compulsive sexual behaviour disorder: A neuroimaging meta-analysis.Journal of behavioral addictions · 2026Pooled it
- Compulsive sexual behavior disorder (CSBD) and problematic pornography use (PPU): A comprehensive, interdisciplinary, and expert-informed narrative review with suggested future directions.Journal of behavioral addictions · 2026Review
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Authors and funding
5 authors.
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Abstract
Background and aims: Despite the inclusion of Compulsive Sexual Behavior Disorder (CSBD) in the ICD-11, there are many open questions on its neuronal pathogenesis, especially regarding the role of the amygdala. In this study, we aimed to further unravel this issue via a parcellation method based on Recurrence Quantification Analysis (RQA). Methods: The RQA pipeline was applied to resting-state functional magnetic resonance imaging data from 45 heterosexual males with CSBD and 26 Healthy Controls. Each amygdala was divided into two subdivisions in each group. In the CSBD group, the scores of psychological questionnaires were used as covariates in a second-level seed-to-voxel connectivity analysis with the amygdala as a region of interest. Results: Obtained parcellations revealed bilateral differences in the sizes of dorsomedial (DM) and ventrolateral (VL) amygdala between groups. Mean values of Shannon's Entropy in the left DM and right VL amygdala correlated negatively with depression level, anxiety, and impulsivity, which might represent a vulnerability to CSBD, but only the right VL was implicated in the severity of CSBD symptoms. Multiple correlations between resting-state functional connectivity of the amygdala subdivisions and CSBD severity were observed, especially between the left VL amygdala and several default mode network nodes. Discussion and Conclusions: This is the first attempt to explore the role of the amygdala in CSBD by a parcellation method. Our results suggest the importance of the right VL amygdala in understanding the pathogenesis of the severity of CSBD symptoms, which highlights the rising need to explore the amygdala as a complex structure with diverse functions.
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