Evidence map›Paper›PMID 40063082›Full record

ArticleeLife2025

Amidase and lysozyme dual functions in TseP reveal a new family of chimeric effectors in the type VI secretion system.

Zeng-Hang Wang, Ying An, Ting Zhao, Tong-Tong Pei, Dora Yuping Wang, Xiaoye Liang, Wenming Qin, Tao Dong

Abstract read
In one paragraph

Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Dissecting the antibacterial functions of the T6SS-2 cluster inApplied and environmental microbiology · 2025
    Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Zeng-Hang WangState Key Laboratory of Microbial Metabolism, Joint International Research Laboratory of Metabolic & Developmental Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China.ORCID https://orcid.org/0009-0004-0532-1070
Ying AnDepartment of Immunology and Microbiology, School of Life Sciences, Guangming Advanced Research Institute, Southern University of Science and Technology, Shenzhen, China.ORCID https://orcid.org/0000-0002-8536-6954
Ting ZhaoNational Facility for Protein Science in Shanghai, Shanghai Advanced Research Institute, Chinese Academy of Sciences, Shanghai, China.
Tong-Tong PeiDepartment of Immunology and Microbiology, School of Life Sciences, Guangming Advanced Research Institute, Southern University of Science and Technology, Shenzhen, China.ORCID https://orcid.org/0009-0004-8241-8896
Dora Yuping WangDepartment of Immunology and Microbiology, School of Life Sciences, Guangming Advanced Research Institute, Southern University of Science and Technology, Shenzhen, China.
Xiaoye LiangDepartment of Immunology and Microbiology, School of Life Sciences, Guangming Advanced Research Institute, Southern University of Science and Technology, Shenzhen, China.
Wenming QinNational Facility for Protein Science in Shanghai, Shanghai Advanced Research Institute, Chinese Academy of Sciences, Shanghai, China.
Tao DongDepartment of Immunology and Microbiology, School of Life Sciences, Guangming Advanced Research Institute, Southern University of Science and Technology, Shenzhen, China.ORCID https://orcid.org/0000-0003-3557-1850

Funding

National Key Research and Development Program of China 2020YFA0907200National Natural Science Foundation of China 32030001
6 · The paper itself

Abstract

Peptidoglycan (PG) serves as an essential target for antimicrobial development. An overlooked reservoir of antimicrobials lies in the form of PG-hydrolyzing enzymes naturally produced for polymicrobial competition, particularly those associated with the type VI secretion system (T6SS). Here, we report that a T6SS effector TseP, from

Indexed as

AeromonasAmidohydrolasesBacterial ProteinsMuramidaseType VI Secretion SystemsPeptidoglycanamidaseAmidohydrolasesBacterial ProteinsMuramidasePeptidoglycanType VI Secretion SystemsA. dhakensisamidaseeffectorinfectious diseaseinterspecies competitionlysozymemicrobiologyT6SS

Identifiers

PMID40063082
PMCPMC11893102

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.