ArticleClinical and experimental immunology1985
Plasma membrane antigens on light density and activated human blood eosinophils.
Article in Clinical and experimental immunology, 1985. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 24 citations in OpenAlex.
- Article
- Human eosinophils stimulate DNA synthesis and matrix production in dermal fibroblasts.Archives of dermatological research · 1994Article
- Shape changes, exocytosis, and cytosolic free calcium changes in stimulated human eosinophils.The Journal of clinical investigation · 1991Article
- Characteristics of an anti-eosinophil monoclonal antibody that recognizes granulocytes from patients with blood eosinophilia but not from subjects without eosinophilia.Clinical and experimental immunology · 1991Article
- The effects of recombinant granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin-3 on the secretory capacity of human blood eosinophils.Clinical and experimental immunology · 1990Article
- Autoreactive eosinophils associated with spontaneous autocytotoxicity in bronchial asthma.Agents and actions · 1988Article
- Eosinophils. Assays and interpretation.Clinical reviews in allergy · 1988Review
- The effects of eosinophil activating factor on IgG-dependent sulphidopeptide leukotriene generation by human eosinophils.Clinical and experimental immunology · 1986Article
- Functional study of a monoclonal antibody to IgE Fc receptor (Fc epsilon R2) of eosinophils, platelets, and macrophages.The Journal of experimental medicine · 1986Article
- Monoclonal antibodies to human eosinophil plasma membrane antigens enhance the secretion of eosinophil cationic protein.Clinical and experimental immunology · 1986Article
- Eosinophils as effector cells in immunity and hypersensitivity disorders.Clinical and experimental immunology · 1985Review
- New properties and roles for eosinophils in disease: discussion paper.Journal of the Royal Society of Medicine · 1985Review
- Eosinophilic disorders affecting the myocardium and endocardium: a review.Heart and vessels. Supplement · 1985Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In order to study the membrane events which lead to human blood eosinophil activation and degranulation, six clone of mouse monoclonal antibodies were made to isolated blood eosinophils from a patient with the hypereosinophilic syndrome (HES). The antibodies were specific for the plasma membranes of blood eosinophils and neutrophils, eosinophil myelocytes and haemopoietic cell lines. A higher proportion of blood eosinophils from eight patients with the HES bound these antibodies compared to normal individuals. Five antibodies stained intermediate density eosinophils preferentially, and one stained the light density eosinophils most strongly. Normal blood eosinophils were induced to express more of these antigens either by culture alone (two antibodies) or culture with monocyte culture supernatant which activates eosinophils for increased cytotoxic capacity (four antibodies). It was concluded that several of the principal antigens on the eosinophil plasma membrane are also present on neutrophils and immature haemopoietic cells, and that their expression in mature blood eosinophils is related to the extent of eosinophil activation and degranulation. It is suggested that these antigens may be useful in studying the ways in which eosinophils alter their plasma membrane during activation and degranulation in vitro, and in the blood of patients with an eosinophilia.
Indexed as
Identifiers
4006306PMC1577022W2419314518What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.