Evidence map›Paper›PMID 40062897›Full record

ArticleApplied and environmental microbiology2025

Highly efficient CRISPR-Cas9 base editing in

Hung-Chun Lin, Wan-Chi Hsiao, Ya-Chen Hsu, Meng-Chieh Lin, Cheng-Chih Hsu, Mingzi M Zhang

Abstract read
In one paragraph

Article in Applied and environmental microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Enhanced editing ofApplied and environmental microbiology · 2026
    Article
  6. Occurrence and applications of CRISPR-Cas systems in bifidobacteria.Applied and environmental microbiology · 2026
    Review
  7. Review
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Hung-Chun Lin *Department of Chemistry, National Taiwan University, Taipei, Taiwan.
Wan-Chi Hsiao *Institute of Biotechnology, National Tsing Hua University, Hsinchu, Taiwan.
Ya-Chen HsuDepartment of Chemistry, National Taiwan University, Taipei, Taiwan.ORCID 0000-0003-1202-0132
Meng-Chieh LinDepartment of Chemistry, National Taiwan University, Taipei, Taiwan.
Cheng-Chih HsuDepartment of Chemistry, National Taiwan University, Taipei, Taiwan.ORCID 0000-0002-2892-5326
Mingzi M ZhangInstitute of Molecular and Genomic Medicine, National Health Research Institutes, Miaoli, Taiwan.ORCID 0000-0002-1213-3340

Funding

National Health Research Institutes EX110-MG-113-SP-01,NHRI-EX113-11003BCNational Science and Technology Council MOST 112-2113-M-002-018-MY2
6 · The paper itself

Abstract

Intestinal microbiota members of the

Indexed as

BifidobacteriumCRISPR-Cas SystemsGene EditingDNA Restriction-Modification EnzymesGastrointestinal MicrobiomeGenome, BacterialPlasmidsDNA Restriction-Modification EnzymesBifidobacteriumCRISPR-CasDNA methylationmetabolic perturbationrestriction modification systemsstrain engineering

Identifiers

PMID40062897
PMCPMC12016496

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.