ArticleMicrobiology spectrum2025
Evaluation of hepatitis A virus recombinant proteins for detecting anti-HAV IgM and IgG antibodies.
Article in Microbiology spectrum, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
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Authors and funding
4 authors.
Funding
Abstract
Hepatitis A virus (HAV) is a major causative agent of self-limiting liver infections. India was highly endemic for HAV in the past; children were exposed to the virus at an early age without any disease symptoms and developed lifelong immunity. With improvements in living conditions, an epidemiological transition is occurring. There is a significant increase in hepatitis A outbreaks involving adolescents and young adults. The gold standard for hepatitis A diagnosis is anti-HAV IgM antibodies. Although antibody responses are primarily targeted against HAV structural proteins (capsid proteins), non-structural proteins are also immunogenic. In the present study, we expressed HAV capsid proteins VP1-2A, VP0 (VP4 + VP2), VP3, and non-structural protein 3C IMPORTANCE: Hepatitis A was highly endemic in India earlier. With recent developments, there is a shift in the endemicity to intermediate levels. This has resulted in the occurrence of hepatitis outbreaks with symptomatic infections in adolescents and adults. Occasionally, the disease manifestations are serious, leading to acute liver failure. In such a situation, there is a need for a timely diagnosis of the infection.
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