ArticleTurkish journal of obstetrics and gynecology2025
Association study of
Article in Turkish journal of obstetrics and gynecology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
4 authors.
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Abstract
Objective: Recurrent spontaneous abortion (RSA), characterized by multiple miscarriages without a known cause, includes both genetic and non-genetic factors. In this research, we studied the association between two polymorphisms of the Materials and Methods: This was a case-control study involving 62 patients with a history of at least two RSA of unknown etiology, as well as 66 healthy individuals. Clinical factors were analyzed. Genomic DNA was extracted from whole blood. Genotyping was performed using amplification refractory mutation system-polymerase chain technique to investigate two single nucleotide polymorphisms (SNPs) of Results: Allelic and genotypic frequencies as well as dominant, recessive and over dominant models for two SNPs, rs1042522 and rs1800871, were investigated. No significant association with RSA (p>0.05) was found. The combination of the homozygote CC for the polymorphism rs1042522 in the Conclusion: Limited studies have been conducted on the association between these two polymorphisms and RSA, and conflicting results have been obtained. Further investigation with a larger sample size may confirm results. Genetic research, such as this, helps understand genetic factors associated with the risk of RSA.
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