Evidence map›Paper›PMID 40062665›Full record

ArticleAngewandte Chemie (International ed. in English)2025

Transaminase-Triggered Cascades for the Synthesis and Dynamic Kinetic Resolution of Chiral N-Heterocycles.

Adam O'Connell, Marianne B Haarr, James Ryan, Xingxing Xu, Aoife Martin, Simon N Smith, Nadia Elghobashi-Meinhardt, Patricia Fleming, Beatriz Maciá, Vittorio Caprio and 1 more

Abstract read
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In one paragraph

Article in Angewandte Chemie (International ed. in English), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Adam O'ConnellSchool of Chemistry, University College Dublin, Belfield, Dublin, 4, Ireland.
Marianne B HaarrSchool of Chemistry, University College Dublin, Belfield, Dublin, 4, Ireland.
James RyanSchool of Chemistry, University College Dublin, Belfield, Dublin, 4, Ireland.
Xingxing XuSchool of Chemistry, University College Dublin, Belfield, Dublin, 4, Ireland.
Aoife MartinSchool of Chemistry, University College Dublin, Belfield, Dublin, 4, Ireland.
Simon N SmithSchool of Chemistry, University College Dublin, Belfield, Dublin, 4, Ireland.
Nadia Elghobashi-MeinhardtSchool of Chemistry, University College Dublin, Belfield, Dublin, 4, Ireland.
Patricia FlemingSchool of Chemistry, University College Dublin, Belfield, Dublin, 4, Ireland.
Beatriz MaciáFaculty of Science & Engineering, Division of Chemistry & Environmental Science, Manchester Metropolitan University, Chester Street, Manchester, M1 5GD, UK.
Vittorio CaprioFaculty of Science & Engineering, Division of Chemistry & Environmental Science, Manchester Metropolitan University, Chester Street, Manchester, M1 5GD, UK.
Elaine O'ReillySchool of Chemistry, University College Dublin, Belfield, Dublin, 4, Ireland.

Funding

Taighde Éireann - Research Ireland 12/RI/2341Taighde Éireann - Research Ireland 19/FFP/6469Taighde Éireann - Research Ireland GOIPG/2023/2755Taighde Éireann - Research Ireland Laureate Award programme BINDCAT IRCLA/2022/2810
6 · The paper itself

Abstract

Biocatalysis is now a well-established branch of catalysis and the growing toolbox of natural, evolved and designer enzymes is enabling chemistry previously deemed inaccessible. However, most enzyme methodologies have been developed for functional group interconversions, such as the conversion of a ketone into an amine or alcohol, and do not result in the generation of significant 3D molecular complexity. The application of enzyme-triggered reaction cascade methodologies has the potential to transform simple substrates into complex sp

Indexed as

Asymmetric synthesisAza‐Michael reactionBiocatalysisHeterocyclesTransaminase

Identifiers

PMID40062665
PMCPMC12087864

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.