Evidence map›Paper›PMID 40062406›Full record

ReviewGut microbes2025

Microbiota transplant therapy in inflammatory bowel disease: advances and mechanistic insights.

Daphne Moutsoglou, Pavithra Ramakrishnan, Byron P Vaughn

Abstract readReview
In one paragraph

Review in Gut microbes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Multifunctional Cu-doped MnMaterials today. Bio · 2026
    Article
  2. Article
  3. Article
  4. Recent advances in the positive role ofFrontiers in immunology · 2026
    Review
  5. Review
  6. Journal of medical microbiology · 2026
    Review
  7. Review
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Daphne MoutsoglouGastroenterology Section, Minneapolis VA Health Care System, Minneapolis, MN, USA.ORCID 0000-0002-4071-3756
Pavithra RamakrishnanDepartment of Medicine, University of Minnesota, Minneapolis, MN, USA.ORCID 0009-0004-8909-5479
Byron P VaughnDivision of Gastroenterology, Hepatology, and Nutrition, University of Minnesota, Minneapolis, MN, USA.ORCID 0000-0001-5081-3761

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Microbiota transplant therapy is an emerging therapy for inflammatory bowel disease, but factors influencing its efficacy and mechanism remain poorly understood. In this narrative review, we outline key elements affecting therapeutic outcomes, including donor factors (such as age and patient relationship), recipient factors, control selection, and elements impacting engraftment and its correlation with clinical response. We also examine potential mechanisms through inflammatory bowel disease trials, focusing on the interplay between the microbiota, host, and immune system. Finally, we briefly explore potential future directions for microbiota transplant therapy and promising emerging treatments.

Indexed as

Fecal Microbiota TransplantationGastrointestinal MicrobiomeInflammatory Bowel DiseasesAnimalsHumansTreatment Outcomecrohn’s diseaseFecal microbiota transplantationinflammatory bowel diseasemicrobiomemicrobiota transplant therapyulcerative colitis

Identifiers

PMID40062406
PMCPMC11901402

What OpenQuestion holds

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LicenceCC0
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.