Evidence map›Paper›PMID 40062390›Full record

ArticleAmerican journal of physiology. Renal physiology2025

TNF inhibits NKCC2 phosphorylation by a calcineurin-dependent pathway.

Shoujin Hao, Anna Pia Lasaracina, Jarred Epps, Nicholas R Ferreri

Abstract read
In one paragraph

Article in American journal of physiology. Renal physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Shoujin HaoDepartment of Pharmacology, New York Medical College, Valhalla, New York, United States.
Anna Pia LasaracinaDepartment of Pharmacology, New York Medical College, Valhalla, New York, United States.ORCID 0009-0001-2754-0272
Jarred EppsDepartment of Pharmacology, New York Medical College, Valhalla, New York, United States.
Nicholas R FerreriDepartment of Pharmacology, New York Medical College, Valhalla, New York, United States.ORCID 0000-0001-5097-9956

Funding

Regulation of NKCC2 isoforms and blood pressure by tumor necrosis factor-alphaR01HL153525 · NHLBI · NEW YORK MEDICAL COLLEGE · PI FERRERI, NICHOLAS R · 2021 to 2024
$1.8M
Thick ascending limb-derived TNF, salt sensitivity, and blood pressure regulationR01HL133077 · NHLBI · NEW YORK MEDICAL COLLEGE · PI FERRERI, NICHOLAS R · 2016 to 2019
$1.6M
HHS | National Institutes of Health (NIH) RO1 HL153525NHLBI NIH HHS R01 HL133077NHLBI NIH HHS R01 HL153525
6 · The paper itself

Abstract

We previously demonstrated that tumor necrosis factor-alpha (TNF) inhibits Na

Indexed as

CalcineurinLoop of HenleSolute Carrier Family 12, Member 1Tumor Necrosis Factor-alphaAnimalsCells, CulturedMaleMiceMice, Inbred C57BLPhosphorylationSignal TransductionCalcineurinSlc12a1 protein, mouseSolute Carrier Family 12, Member 1Tumor Necrosis Factor-alphacalcineurin inhibitorscalcineurin isoformsNKCC2 phosphorylationTNF

Identifiers

PMID40062390
PMCPMC12048884

What OpenQuestion holds

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LicenceTDM
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.