Evidence map›Paper›PMID 40062342›Full record

ReviewBioactive materials2025

Advances and challenges in biomaterials for tendon and enthesis repair.

Haiying Zhou, Yangwu Chen, Wu Yan, Xiao Chen, Yin Zi

Abstract readReview
In one paragraph

Review in Bioactive materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Haiying ZhouDepartment of Orthopedic Surgery of Sir Run Run Shaw Hospital, and Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou, China.
Yangwu ChenDepartment of Rehabilitation Medicine, Center for Rehabilitation Medicine, Rehabilitation & Sports Medicine Research Institute of Zhejiang Province, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, China.
Wu YanDepartment of Sports Medicine & Orthopedic Surgery, The Second Affiliated Hospital, and Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cells and Regenerative Medicine, Zhejiang University School of Medicine, Hangzhou, China.
Xiao ChenDepartment of Sports Medicine & Orthopedic Surgery, The Second Affiliated Hospital, and Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cells and Regenerative Medicine, Zhejiang University School of Medicine, Hangzhou, China.
Yin ZiDepartment of Orthopedic Surgery of Sir Run Run Shaw Hospital, and Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tendon and enthesis injuries are a global health problem affecting millions of people, causing huge medical expenditure and labor loss every year. However, due to their intricate tissue architecture, unique mechanical properties, and especially their sluggish and limited innate regenerative capacity, repairing these injuries remains a formidable clinical challenge. Here, we present a comprehensive review of biomaterials advances in tendon and enthesis repair recently. These biomaterials are categorized into two primary groups based on their potential clinical application conditions: biomaterials for T/E repairing and biomaterials for T/E replacement. The T/E repairing biomaterials were further divided into two groups: mechanical-enhanced biomaterials and bioactive biomaterials, according to the approaches they used to improve sutured tendon healing. We delve into the characteristics and underlying mechanisms of these various biomaterials to gain a deeper understanding of the current landscape in tendon and enthesis repair biomaterials. This review aims to highlight the prominent advancements while identifying the remaining gaps, ultimately inspiring future biomaterial design strategies.

Indexed as

Bioactive biomaterialsBiomaterials for T/E replacementEnthesisMechanical enhanced biomaterialsRepairTendon

Identifiers

PMID40062342
PMCPMC11889517

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.