ReviewFrontiers in cellular neuroscience2025
Spinal astrocytes involved in the pathogenesis and treatment of neuropathic pain.
Review in Frontiers in cellular neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Glial cells in neuropathic pain.Physiological reviews · 2026Review
- Spinal Cord Stimulation Alleviates Neuropathic Pain Involves Regulation of the CaCellular and molecular neurobiology · 2026Article
- Mechanisms and Clinical Application Progress of Exercise in the Treatment of Neuropathic Pain.Cellular and molecular neurobiology · 2026Review
- Precuneus hyperexcitability mediates inflammatory-driven pain hypersensitivity following sleep disruption: a multimodal neuroimaging study.Frontiers in immunology · 2026Article
- Review
- Astrocytes in Neuropathic Pain: Mechanistic and Global Insights.Pain research & management · 2026Review
- Dual Role of the Spinal Endocannabinoid System in Response to Noxious Stimuli: Antinociceptive Pathways and Neuropathic Pain Mechanisms.International journal of molecular sciences · 2025Review
- Cancer pain: molecular mechanisms and management.Molecular biomedicine · 2025Review
- Evaluation of acupuncture on pain intensity and sleep quality in patients with neuropathic pain following spinal cord injury.American journal of translational research · 2025Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neuropathic pain is a common and severe type of chronic pain, and its pathogenesis has not been fully defined. Increasing evidence shows that spinal astrocytes play indispensable roles in the occurrence and development of neuropathic pain. Most studies have suggested that activated astrocytes can crosstalk with other glial cells and neurons through morphological and functional changes, exacerbating the development of pain. However, reactive astrocytes have a dual role. As a defense mechanism, reactive astrocytes have roles in increasing neuroprotection and stimulating neurogenesis. Studies have demonstrated a potentially beneficial role for astrocyte activation in neuropathic pain. In addition, the therapeutic mechanisms of multiple drugs and neuromodulatory techniques are thought to be related to astrocytes. This review highlights the recent advances and significance of spinal astrocytes, emphasizing the need for a better understanding of their roles in the pathogenesis and treatment of neuropathic pain.
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Registered trials
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