Evidence map›Paper›PMID 40062135›Full record

ArticleCureus2025

Acquired Hepatocerebral Degeneration in a Septic Patient: Hospital Course and MRI Findings.

Ethan L Porter, Alexandria R Koney, Alexia R Jauregui, Emelie N McQuitty, Courtney T Huynh, Rita B Khouri, Alisha Kashyap, Matthew T Wong

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ethan L PorterInternal Medicine, John P. and Kathrine G. McGovern Medical School, University of Texas Health Science Center-Houston, Houston, USA.
Alexandria R KoneyInternal Medicine, John P. and Kathrine G. McGovern Medical School, University of Texas Health Science Center-Houston, Houston, USA.
Alexia R JaureguiInternal Medicine, John P. and Kathrine G. McGovern Medical School, University of Texas Health Science Center-Houston, Houston, USA.
Emelie N McQuittyInternal Medicine, John P. and Kathrine G. McGovern Medical School, University of Texas Health Science Center-Houston, Houston, USA.
Courtney T HuynhInternal Medicine, John P. and Kathrine G. McGovern Medical School, University of Texas Health Science Center-Houston, Houston, USA.
Rita B KhouriInternal Medicine, John P. and Kathrine G. McGovern Medical School, University of Texas Health Science Center-Houston, Houston, USA.
Alisha KashyapInternal Medicine, John P. and Kathrine G. McGovern Medical School, University of Texas Health Science Center-Houston, Houston, USA.
Matthew T WongInternal Medicine, John P. and Kathrine G. McGovern Medical School, University of Texas Health Science Center-Houston, Houston, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acquired hepatocerebral degeneration (AHD) is a rare neuropsychiatric disorder affecting cirrhotic patients, often presenting with neuropsychiatric symptoms triggered by a precipitating factor. Magnetic resonance imaging (MRI) showing T1 hyperintensities in the globus pallidus is diagnostic. In this case report, a 40-year-old female patient with alcoholic cirrhosis presented with generalized swelling, jaundice, fever, and signs of septic shock. After stabilization, changes in cognition while this patient was hospitalized prompted the management of several different factors, including the underlying infection, hypernatremia, vitamin deficiency, alcohol withdrawal, and hyperammonemia. Infectious disease consultation helped determine the antibiotic selection and dosage for bacteremia and later concerns for meningitis. This case report illustrates the role of MRI in diagnosing AHD and highlights the importance of how managing precipitating factors such as infection and hyperammonemia is key to improving cognitive status.

Indexed as

acquired hepatocerebral degenerationalcohol abusealcoholic cirrhosisglobus pallidushyperammonemiamri findingseptic shock

Identifiers

PMID40062135
PMCPMC11885173

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.