ReviewCureus2025
The Efficacy of Biobrane in Managing Superficial Paediatric Burn Injuries: A Systematic Review and Meta-Analysis.
Review in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- [Efficacy of artificial dermis in repairing small to medium-sized deep partial-thickness scalds in infants and young children].Zhonghua shao shang yu chuang mian xiu fu za zhi · 2025Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Burn injuries in the paediatric population are common and account for a substantial proportion of hospital attendances, leading to a growing focus on optimising wound care to enhance healing, reduce discomfort and minimise the need for frequent dressing changes. Traditional dressings for superficial burns in children have inherent limitations that may hinder these goals. Biobrane (Dow Hickman/Bertek Pharmaceuticals, Sugar Land, TX), a semi-permeable silicone device embedded with a nylon mesh and a porcine-derived collagen matrix, offers a promising alternative with advantages such as improved wound healing, reduced pain and fewer dressing changes. This systematic review and meta-analysis, conducted in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, assessed the efficacy of Biobrane by analysing data from MEDLINE, PubMed, EMCare, Cochrane Cochrane Central Register of Controlled Trials and additional clinical trial registries up to 8 June 2024. Primary outcomes included burn wound healing time, hospital length of stay and infection rate, while secondary outcomes assessed the need for split-thickness skin grafts (STSGs), pain and the number of dressing changes. Data synthesis using the OpenMetaAnalyst software (Brown University, Providence, RI) encompassed 781 burn wounds across 12 studies. The results showed that Biobrane significantly shortened wound healing time (mean difference, MD: 5.168 days, p = 0.001) and hospital length of stay (MD: 2.009 days, p < 0.001) compared to standard dressings. The infection rate was comparable (odds ratio, OR: 2.457, p = 0.132), and there was no difference in the requirement for STSGs (OR: 0.965, p = 0.956). This systematic review and meta-analysis demonstrate that Biobrane is an effective treatment for superficial paediatric burn injuries, offering faster wound healing, reduced pain and shorter hospital stays compared to traditional dressings.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.