ReviewCureus2025
Comparison of Imaging Modalities in Differentiating Cerebral Neoplastic Lesions and Post-radiation Necrosis.
Review in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Dynamic Contrast-Enhanced MRI in Neuro-Oncology: A Narrative and Translational Review.Brain sciences · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neuroimaging of cerebral neoplastic lesions and post-radiation necrosis (PRN) presents significant challenges due to their overlapping features, making differentiation difficult. The use of various imaging modalities in association with radiation therapy introduces potential risks and prognostic variations that can affect lesion physiology. Patients who undergo radiation treatment inevitably experience changes influenced by factors such as radiation dose, brain volume, and tumor fraction size. Additionally, vascular injury and the inflammatory response associated with radiation contribute to alterations observed in neuroimaging. This literature review aims to provide a comparative overview of imaging studies to highlight the optimal modality to distinguish between PRN and tumor recurrence. The imaging modalities assessed included dynamic contrast-enhanced (DCE) and dynamic susceptibility contrast (DSC) MR-perfusion, MR-spectroscopy, intravoxel incoherent motion (IVIM) perfusion, and nuclear medicine studies, including 18F-fluoro-ethyl-1-tyrosine positron emission tomography (18F-FET PET) and 11C-methionine PET (11C MET-PET). The improvement of diagnostic accuracy in multimodal imaging must be further investigated to improve clinical patient management and outcomes of tumor reoccurrence.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.