ArticleCureus2025
Amputation Versus Limb-Salvage Surgery as Treatments for Pediatric Bone Sarcoma: A Comparative Study of Survival, Function, and Quality of Life.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Outcomes and Prognostic Factors in Tumor-Related Amputations: A Retrospective Cohort Study of 132 Cases over Two Decades.Journal of clinical medicine · 2026Article
- Pelvic Floor Functionality and Outcomes in Oncologic Patients Treated with Pelvic Bone Resection.Cancers · 2025Article
- Factors influencing imaging and functional recovery outcomes after limb-salvage surgery in patients with bone tumors: a retrospective case-control study.American journal of cancer research · 2025Article
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Authors and funding
7 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundPediatric appendicular bone sarcomas, including osteosarcoma and Ewing's sarcoma, are rare but aggressive malignancies that have a profound impact on survival, physical function, and quality of life (QoL). Treatment options usually involve either limb-salvage surgery (LSS) or amputation (AMP), although evidence about outcomes among these approaches is still limited.
methodsA retrospective cohort study was conducted involving pediatric cases treated for appendicular bone sarcomas between 2000 and 2021 at the Instituto Português de Oncologia de Lisboa (IPOL), a Portuguese oncology center in Lisbon. It evaluated functional and QoL outcomes and survival. Patients were stratified by surgical approach (LSS vs. AMP) and evaluated by validated outcome tools, including the Toronto Extremity Salvage Score (TESS) and the Medical Outcomes Study Short-Form 36 version 2 (MOS SF-36v2) QoL questionnaire. P-values <0.05 were considered significant.
resultsA total of 62 patients were included, with an overall five-year survival rate of 38%. Poorer survival outcomes were recorded among those presenting with metastatic disease, larger tumor sizes (>8 cm), and those who underwent AMP. Limb-salvage surgery was performed in 59.7% of cases and presented higher mean functional scores (88.4%) compared with AMP (79%). The QoL scores varied, with LSS patients reporting better outcomes in physical and emotional domains. Patients from Portuguese-speaking African countries (PSAC) had poorer survival rates, a finding that reflects disparities that could be related to advanced disease presentation and limited health resources.
conclusionLimb-salvage surgery had better functional outcomes and QoL compared to AMP. However, survival of these patients remains a challenge, especially for those from resource-limited settings. These results highlight the need for early diagnosis, improvement in access to healthcare, and further research to improve treatment.
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