Evidence map›Paper›PMID 40061959›Full record

ArticleFrontiers in pharmacology2025

Elucidation of

Mubashir Zafar, Sadaf Anwar, Malik Asif Hussain, Naveed Iqbal, Abrar Ali, Sadaf, Mohammad Zeeshan Najm, Mohd Adnan Kausar

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mubashir ZafarDepartment of Family and Community Medicine, College of Medicine, University of Ha'il, Hail, Saudi Arabia.
Sadaf AnwarDepartment of Biochemistry, College of Medicine, University of Ha'il, Hail, Saudi Arabia.
Malik Asif HussainDepartment of Pathology, College of Medicine, University of Ha'il, Hail, Saudi Arabia.
Naveed IqbalDepartment of Obstetrics and Gynecology, College of Medicine, University of Ha'il, Hail, Saudi Arabia.
Abrar AliDepartment of Ophthalmology, College of Medicine, University of Ha'il, Hail, Saudi Arabia.
SadafDepartment of Biotechnology, Jamia Millia Islamia, New Delhi, India.
Mohammad Zeeshan NajmSchool of Biosciences, Apeejay Stya University, Gurugram, Haryana, India.
Mohd Adnan KausarDepartment of Biochemistry, College of Medicine, University of Ha'il, Hail, Saudi Arabia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Many human tumours have hyperactive signal transducer and activator of transcription 3 (STAT3, positioning it as a prime target for natural compounds with anticancer properties. This study investigated three small-molecule STAT3 inhibitors derived from Material and methods: The compounds were explored through virtual screening and molecular dynamics (MD) simulations to understand the intracellular processing of activated STAT3. The biological effects of these STAT3 inhibitors on human cancer cells were assessed via simulation. Further, Results and discussion: It is revealed through results that active components in these compounds inhibited cancer cell migration and invasion and suppressed the proliferation of noncancer cells. Moreover, these natural compounds from

Indexed as

apoptosiscancerMD simulationmolecular dockingSTAT3

Identifiers

PMID40061959
PMCPMC11885254

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.