ArticleFrontiers in pharmacology2025
Exploration the therapeutic effects of sodium houttuyfonate combined with penicillin G on methicillin resistant
Article in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Beyond susceptibility testing: traditional Chinese medicine-associated compounds as candidate antibiotic adjuncts in chronic-wound biofilms.Frontiers in cellular and infection microbiology · 2026Review
- Discovery of Novel Antimicrobial-Active Compounds and Their Analogues by In Silico Small Chemical Screening TargetingMolecules (Basel, Switzerland) · 2025Article
- Intraparenchymal Penicillin G Injection Promotes Wound Healing and Lowers POPF in Pigs After Pancreatic Surgery.Biomedicines · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Methicillin resistant Methods: Evaluating the antibacterial effect of drugs through Result: The MIC of SH and PNC are 60-80 μg/mL and 40-70 U/mL, respectively. The FICI of the combined group is 0.375-0.5625, and the optimal drug ratio is SH20 μg/mL + PNC15u/mL. The number of central granulocytes infiltrated in the combined group was less than that in other groups, and the levels of IL-6 and TNF-α were significantly reduced. In addition, the collagen fibers in the wound were significantly increased. Thirteen target genes were predicted through network pharmacology, among which the core targets were IL1B, IL6, MMP9, IFNG, and TNF. SH and PNG have shown good binding potential with various targets in molecular docking. Among the 83 potential pathways of action, IL-17 signaling pathway is considered a key pathway for promoting wound healing. Conclusion: Sodium houttuyfonate combined with penicillin G can inhibit bacterial growth in MRSA infected wounds in rats, reduce neutrophil infiltration, promote collagen fiber generation in wounds, and decrease the expression levels of inflammatory factors IL-6 and TNF-α in the blood of rats after MRSA infection. It promotes wound healing through multiple targets and pathways, and preliminarily reveals the drug's targets and molecular mechanisms.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.