ArticleFrontiers in oncology2025
Mast cell - tumor cell interaction related gene and microRNA expression profiles in oral squamous cell carcinoma.
Article in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Development of a cancer metastasis-associated risk model via multi-machine-learning algorithms for prognostic risk evaluation and clinical application in oral squamous cell carcinoma.Journal of translational medicine · 2025Article
- Chemokines and their receptors in oral squamous cell carcinoma: mechanisms, clinical significance, and therapeutic implications.Frontiers in immunology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Backround: Mast cells (MCs) play a crucial role in the tumor microenvironment (TME) of oral squamous cell carcinoma (OSCC), significantly impacting patient prognosis. This study aimed to investigate the gene and microRNA (miRNA) expression profiles of MCs and OSCC cells following co-culture, providing valuable insights into the molecular background of their functional interactions. Methods: The human OSCC cell line PCI-13 and the human MC cell line LUVA were initially cultured separately under identical experimental conditions and subsequently co-cultured for 48-72h. Transcriptome analysis of differentially expressed genes (DEGs) and sequencing of differentially expressed miRNAs were performed and analyzed using bioinformatics tools. Additionally, key genes and miRNAs identified in OSCC were assessed for their prognostic relevance in head and neck tumors using freely available online databases. Results: The analyses revealed distinct DEG profiles between OSCC cells and MCs under monoculture and co-culture conditions. Notable findings include DEGs involved in chemokine signaling - particularly the CCL2/CCR2 axis - TGF-β signaling, toll-like receptor (TLR) expression, and key intracellular pathways such as PI3K/Akt, JAK/STAT, Ras/Raf/MAPK, and IP3 in both cell types. Additionally, specific miRNAs, including miR-142, miR-146a, and miR-223 in tumor cells, as well as miR-381 and miR-379 in MCs, exhibited significant differential expression, highlighting their potential involvement in regulating MC-OSCC interaction. Notably, the expression levels of CCR2, along with miR-142, miR-146a, and miR-223, were identified as prognostically relevant in patients suffering from head and neck tumor. Conclusions: The data highlight the complex and dynamic interplay between MCs and OSCC, driven by key signaling pathways and miRNA regulation. These findings provide a foundation for future functional studies and the possible development of targeted therapies aimed at modulating MC-OSCC interaction within the TME.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.