ArticleFrontiers in oncology2025
Prognostic significance and immune microenvironment infiltration patterns of hypoxia and endoplasmic reticulum stress-related genes in gastric cancer.
Article in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- Transcriptomic profiling identifies NLRP3-associated inflammatory signatures in acute radiation enteritis and characterizes the protective effects of Qing Hua Yi Chang formula.Frontiers in immunology · 2026Article
- AMFR-mediated ER-phagy regulation and therapeutic targeting in osteosarcoma: a multifunctional nanoplatform strategy.Journal of nanobiotechnology · 2025Article
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3 authors.
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Abstract
Background: Gastric cancer (GC) is a prevalent malignant neoplasm within the digestive system, accounting for approximately 740,000 deaths globally each year, significantly impacting patients' quality of life and survival rates. The objective of this investigation was to elucidate the expression patterns of Hypoxia and Endoplasmic Reticulum Stress-related Differentially Expressed Genes (HERSRDEGs) in GC and their association with prognostic outcomes of the patients. Methods: Utilizing The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases, GC datasets were retrieved, and standard normalization was performed. Differential expression analysis was conducted using DESeq2, while somatic mutations and copy number variations were examined using maftools and GISTIC2.0. Spearman's correlation assessed the interplay between HERSRDEGs across datasets. Functional enrichment analyses were carried out using clusterProfiler for Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways, alongside Gene Set Enrichment Analysis (GSEA). A prognostic risk model was obtained by utilizing univariate Cox regression analysis with a survival R package. We employed RT-qPCR to validate the mRNA expression levels of five model genes that impact the prognostic risk of gastric cancer in human gastric adenocarcinoma tissues. Results: The acquired data revealed 19 HERSRDEGs including Conclusion: In conclusion, this investigation elucidates the involvement of HERSRDEGs in GC progression and their potential as prognostic biomarkers.
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