Evidence map›Paper›PMID 40061885›Full record

ReviewInternational journal of nanomedicine2025

Progress in the Application of Novel Nanomaterials in Targeted Therapy for Liver Cancer.

Xin Wei, Weihua Cao, Shiyu Wang, Yaqin Zhang, Zixuan Gao, Shuojie Wang, Linmei Yao, Ziyu Zhang, Xinxin Li, Wen Deng and 2 more

Abstract readReview
In one paragraph

Review in International journal of nanomedicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Xin Wei *Department of Hepatology Division 2, Beijing Ditan Hospital, Capital Medical University, Beijing, 100015, People's Republic of China.
Weihua Cao *Department of Hepatology Division 2, Beijing Ditan Hospital, Capital Medical University, Beijing, 100015, People's Republic of China.
Shiyu Wang *Department of Hepatology Division 2, Beijing Ditan Hospital, Capital Medical University, Beijing, 100015, People's Republic of China.
Yaqin Zhang *Department of Hepatology Division 2, Beijing Ditan Hospital, Capital Medical University, Beijing, 100015, People's Republic of China.
Zixuan GaoDepartment of Hepatology Division 2, Beijing Ditan Hospital, Capital Medical University, Beijing, 100015, People's Republic of China.
Shuojie WangDepartment of Hepatology Division 2, Beijing Ditan Hospital, Capital Medical University, Beijing, 100015, People's Republic of China.
Linmei YaoDepartment of Hepatology Division 2, Beijing Ditan Hospital, Capital Medical University, Beijing, 100015, People's Republic of China.
Ziyu ZhangDepartment of Hepatology Division 2, Beijing Ditan Hospital, Capital Medical University, Beijing, 100015, People's Republic of China.
Xinxin LiDepartment of Hepatology Division 2, Beijing Ditan Hospital, Capital Medical University, Beijing, 100015, People's Republic of China.
Wen DengDepartment of Hepatology Division 2, Beijing Ditan Hospital, Capital Medical University, Beijing, 100015, People's Republic of China.
Yao XieDepartment of Hepatology Division 2, Beijing Ditan Hospital, Capital Medical University, Beijing, 100015, People's Republic of China.
Minghui LiDepartment of Hepatology Division 2, Beijing Ditan Hospital, Capital Medical University, Beijing, 100015, People's Republic of China.ORCID 0000-0003-3233-5473

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In recent years, nanobiotechnology, widely used in hepatoma, holds great promise for improving targeted hepatocarcinoma therapy. On account of the unique properties of low toxicity, good tolerance, biocompatibility, and biodegradability of new nanomaterials, a targeted drug delivery system (TDDS) has been constructed, which can boost the therapeutic effect of hepatoma-targeted drugs, reduce drug toxicity, and minimize off target reactions by enhancing permeability retention effect (EPR) and active targeting, thus improving existing liver cancer targeted therapy strategies. Different nanoparticles have their own advantages and disadvantages. They can be loaded with multiple drugs on the same nanoparticle and can also be surface modified with each other to achieve synergistic anti-tumor effects. This essay provides a comprehensive overview of the current status of targeted therapy for hepatocarcinoma, nanoparticles' structure, advantages and disadvantages of each nanoparticle, and the application progress of nanoparticles in targeted therapy for liver cancer. We hope to provide a basis for the future clinical targeted therapy of hepatoma using nanotechnology.

Indexed as

Antineoplastic AgentsCarcinoma, HepatocellularDrug Delivery SystemsLiver NeoplasmsNanoparticle Drug Delivery SystemAnimalsHumansNanomedicineNanoparticlesAntineoplastic AgentsNanoparticle Drug Delivery Systemdrug deliveryliver cancernanoparticlesnanotechnologytargeted therapy

Identifiers

PMID40061885
PMCPMC11887507

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.