Evidence map›Paper›PMID 40061830›Full record

ArticleOpen medicine (Warsaw, Poland)2025

Sex-specific associations of sex hormone binding globulin and risk of bladder cancer.

Junyong Ou, Hai Bi, Haobin Zhou, Zhanyi Zhang, Peichen Duan, Haoming Yin, Zezhen Zhou, Zhixin Xie, Xiaojun Tian, Jianfei Ye and 1 more

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In one paragraph

Article in Open medicine (Warsaw, Poland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Junyong OuDepartment of Urology, Peking University Third Hospital, Peking University Health Science Center, Beijing, 100191, China.
Hai BiDepartment of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China.
Haobin ZhouThe First Clinical College of Guangzhou Medical University, Guangzhou, Guangdong, 511436, China.
Zhanyi ZhangDepartment of Urology, Peking University Third Hospital, Peking University Health Science Center, Beijing, 100191, China.
Peichen DuanDepartment of Urology, Peking University Third Hospital, Peking University Health Science Center, Beijing, 100191, China.
Haoming YinDepartment of Urology, Peking University Third Hospital, Peking University Health Science Center, Beijing, 100191, China.
Zezhen ZhouDepartment of Urology, Peking University Third Hospital, Peking University Health Science Center, Beijing, 100191, China.
Zhixin XieThe Second Clinical College of Guangzhou Medical University, Guangzhou, Guangdong, 511436, China.
Xiaojun TianDepartment of Urology, Peking University Third Hospital, Peking University Health Science Center, Beijing, 100191, China.
Jianfei YeDepartment of Urology, Peking University Third Hospital, Peking University Health Science Center, 49 North Garden Road, Beijing, 100191, China.
Shudong ZhangDepartment of Urology, Peking University Third Hospital, Peking University Health Science Center, 49 North Garden Road, Beijing, 100191, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Males have a three times higher risk of a diagnosis of bladder cancer (Bca) than females. Sex hormone-binding globulin (SHBG) may be associated with Bca risk. However, the sex-specific role of SHBG in Bca remains unclear. In this study, we aimed to determine the role of SHBG in Bca. Methods: A sex-specific univariable Mendelian randomization (MR) analysis involving 369,426 men and 395,375 women was conducted to assess the causal relationship between SHBG and testosterone and Bca risk. Sensitivity analyses and multivariable MR were conducted to confirm the robustness of our results. Linkage disequilibrium score regression assessed the genetic correlation between these diseases influenced by heredity. Results: Univariable MR results showed that one-SD elevated SHBG was related to a low risk of Bca in males (OR: 0.60, 95% CI: 0.39-0.93; Conclusions: Our findings do not provide evidence to support a causal relationship between SHBG and Bca risk in males although an association was observed in the univariable analysis. Further research is needed to identify the underlying pathways.

Indexed as

bladder cancergenome-wide association studiesrisksex hormone binding globulintestosterone

Identifiers

PMID40061830
PMCPMC11889508

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.