Modulatory Effects of Gingerol in Cancer Cell Growth Through Activation and Suppression of Signal Pathways in Cancer Cell Growth Systemic Review.

Background: Gingerol is a traditional medicinal herb used to treat various cancers. The current review aims to explore the modulatory effects of gingerol on cancer cell growth through the activation and suppression of key signaling pathways involved in cancer progression. Methods: A literature search was conducted on the databases such as PubMed, Cochrane, Google Scholar, and Embase. The inclusion criteria for the study were randomized control trials conducted during 2011-2023. Seven articles were selected for inclusion in the systematic review. Results: There was clinically significant evidence due to intervention in changes of nausea-related quality of life (QoL), overall chemotherapy-induced nausea and vomiting-related QoL, delayed nausea severity, fatigue, low incidence of malnutrition, and a high compliance rate. The findings of the study suggest that 6-gingerol hinders cell viability and induces cell death in prostate cancer cells, which is dependent on time and dose. 6-Gingerol could be developed as a complementary therapy to cisplatin in the management of ovarian cancer, offering a strategy to enhance therapeutic outcomes and minimize toxicity. Conclusions: This systematic review highlights the potential of ginger in malignancy treatment due to its ability to activate and suppress various signaling pathways. The review underscores the need for further in-depth studies and more clinical trials in humans to better understand the precise mechanisms and to validate the efficacy of ginger.