ArticleJournal of pharmacy & bioallied sciences2024
Comparative Study of Noncatheterized and Catheter-Associated Urinary Tract Infections by ESBL-Producing Gram-Negative Bacilli in an Urban Tertiary-Care Center, Salem, Tamil Nadu.
Article in Journal of pharmacy & bioallied sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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4 authors.
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Abstract
Background: Urinary tract infections are frequently caused by Gram-negative bacilli, and timely detection and management of resistant strains and their antimicrobial susceptibilities are crucial. Methods: A six-month study examined Gram-negative bacilli from catheterized and noncatheterized patients, assessing antibiotic susceptibility, minimum inhibitory concentration, and Extended spectrum beta lactamase (ESBL) production genes using real-time Polymerase chain reaction (PCR). Results: Out of 72 isolates, 55.56% were ESBLs, with 65.0% from catheterized and 35.0% from noncatheterized samples. Out of 21 ESBL isolates, 47.62% had cefotaximase M (CTX-M) gene, while 4.76% had sulfhydril variant (SHV) and oxacillinase (OXA) 10/11 genes. Coproduction of CTX-M and SHV was observed. Conclusion: The study reveals multiple ESBL genes co-expression in clinical isolates from catheterized and noncatheterized patients, emphasizing the need for regular monitoring and antibiotic policy development.
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