Evidence map›Paper›PMID 40061632›Full record

ArticleIn silico pharmacology2025

Exploration of novel phytochemicals as α-synuclein aggregation inhibitors in the context of Parkinson's disease therapy: an in-silico approach.

Garima Gupta, Deepika Joshi, Gopeshwar Narayan, Sameer Sharma

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in In silico pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Garima GuptaDepartment of Neurology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, 221005 India.
Deepika JoshiDepartment of Neurology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, 221005 India.
Gopeshwar NarayanDepartment of Molecular and Human Genetics, Institute of Science, Banaras Hindu University, Varanasi, 221005 India.
Sameer SharmaDepartment of Bioinformatics, BioNome, Bangalore, 560043 India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The misfolding and aggregation of alpha-synuclein play a pivotal role in the pathogenesis of Parkinson's disease (PD), contributing to neuronal dysfunction, the formation of Lewy bodies, and the manifestation of motor symptoms characteristic of PD. Understanding these molecular mechanisms is imperative for advancing therapeutic strategies for this neurodegenerative disorder. Current treatment modalities primarily involve dopamine replacement drugs, which fail to halt or slow disease progression. This study employs in-silico methods, including molecular docking and molecular dynamics simulations, to comprehensively evaluate naturally derived phytochemicals (

Indexed as

ADMET analysisIn silicoMolecular dockingMolecular dynamic (MD) stimulationParkinson’sPhytochemical

Identifiers

PMID40061632
PMCPMC11885716

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.