Evidence map›Paper›PMID 40061599›Full record

ArticleWorld journal of gastroenterology2025

Disseminated liver histoplasmosis in an immunocompetent individual cured by liver transplantation and voriconazole from China: A case report.

Chen-Xuan Li, Hao-Dong Chen, Shakoor Kashif, Bin Xie, Jing Luo, Ting Li

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of gastroenterology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Chen-Xuan LiDepartment of Liver Transplantation, The Second Xiang-ya Hospital, Central South University, Changsha 410011, Hunan Province, China.
Hao-Dong ChenDepartment of Liver Transplantation, The Second Xiang-ya Hospital, Central South University, Changsha 410011, Hunan Province, China.
Shakoor KashifDepartment of Liver Transplantation, The Second Xiang-ya Hospital, Central South University, Changsha 410011, Hunan Province, China.
Bin XieDepartment of Liver Transplantation, The Second Xiang-ya Hospital, Central South University, Changsha 410011, Hunan Province, China.
Jing LuoDepartment of Liver Transplantation, The Second Xiang-ya Hospital, Central South University, Changsha 410011, Hunan Province, China.
Ting LiDepartment of Liver Transplantation, The Second Xiang-ya Hospital, Central South University, Changsha 410011, Hunan Province, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHistoplasmosis is a rare infectious condition with mainly pulmonary involvement which is generally self-limiting in immunocompetent individuals. Its manifestation varies and lacks specificity. This study reports a case of primary disseminated liver histoplasmosis in a normal host presenting as liver failure cured by liver transplantation and voriconazole. CASE SUMMARY: A 43-year-old Chinese man with intermittent fever, malaise, jaundice and extreme hepatomegaly for more than 40 days was admitted to the Second Xiang-ya Hospital. The patient was immunocompetent and lacked a definitive history of exposure. His condition deteriorated to liver failure, and he promptly underwent liver transplantation to ensure survival. One year later, the patient presented with severe gastrointestinal symptoms, including fever, abdominal pain, and diarrhea. Subsequently, tissue samples acquired

conclusionIn patients with chronic-hepatitis-B having atypical symptoms, histoplasmosis can be a differential diagnosis. Voriconazole is effective in treating histoplasmosis.

Indexed as

Antifungal AgentsHistoplasmaHistoplasmosisLiver TransplantationVoriconazoleAdultBiopsyChinaDiagnosis, DifferentialHumansImmunocompetenceLiverLiver FailureMaleTreatment OutcomeAntifungal AgentsVoriconazoleCase reportDisseminated histoplasmosisHistoplasmaImmunocompetenceLiver transplantationVoriconazole

Identifiers

PMID40061599
PMCPMC11886043

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.