Evidence map›Paper›PMID 40061518›Full record

ArticleFrontiers in child and adolescent psychiatry2025

Clinical characteristics of depressed children and adolescents with and without suicidal thoughts and behavior: a cross-sectional study.

I Häberling, M Preisig, S Emery, N Baumgartner, M Albermann, M Strumberger, K Schmeck, L Wöckel, S Erb, B Rhiner and 3 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in child and adolescent psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03167307 (OMEGA-3 FATTY ACIDS AS FIRST-LINE TREATMENT IN PAEDIATRIC DEPRESSION. A Phase III, 36-week, Multi-centre, Double-blind, Placebo-controlled Randomized Superiority Study), which is not on this map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03167307 phase3completednot on this map

OMEGA-3 FATTY ACIDS AS FIRST-LINE TREATMENT IN PAEDIATRIC DEPRESSION. A Phase III, 36-week, Multi-centre, Double-blind, Placebo-controlled Randomized Superiority Study

TypeinterventionalSponsorGregor BergerRan2017 to 2022Enrolled257ConditionsDepressionArmsOmega 3 fatty acid, Placebo oil
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

I Häberling *Clinic for Child and Adolescent Psychiatry and Psychotherapy, Psychiatric University Hospital Zurich, Zurich, Switzerland.
M Preisig *Clinic for Child and Adolescent Psychiatry and Psychotherapy, Psychiatric University Hospital Zurich, Zurich, Switzerland.
S EmeryClinic for Child and Adolescent Psychiatry and Psychotherapy, Psychiatric University Hospital Zurich, Zurich, Switzerland.
N BaumgartnerOutpatient Psychology Wil, Psychiatric Hospital St. Gallen Nord, Wil, Switzerland.
M AlbermannClinic for Child and Adolescent Psychiatry and Psychotherapy, Psychiatric University Hospital Zurich, Zurich, Switzerland.
M StrumbergerOutpatient Clinic, Psychiatric Services Lucerne, Lucerne, Switzerland.
K SchmeckDepartment of Clinical Research, University of Basel, Basel, Switzerland.
L WöckelCenter for Child and Adolescent Psychiatry and Psychotherapy, Clienia Littenheid AG, Littenheid, Switzerland.
S ErbSpecial Offers and Projects, Child and Adolescent Services St. Gallen, St. Gallen, Switzerland.
B RhinerChild and Adolescents Psychiatry, Psychiatric Services Thurgau, Weinfelden, Switzerland.
B ContinChild and Adolescent Psychiatry, Psychiatric Services Baselland, Liestal, Switzerland.
S WalitzaClinic for Child and Adolescent Psychiatry and Psychotherapy, Psychiatric University Hospital Zurich, Zurich, Switzerland.
G BergerClinic for Child and Adolescent Psychiatry and Psychotherapy, Psychiatric University Hospital Zurich, Zurich, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: About half of all adolescents with major depressive disorder (MDD) have frequent suicidal thoughts and of those with suicidal ideations, about one-third attempt suicide. Identifying clinical characteristics associated with suicidal ideation and attempts is important for suicide prevention and clinical care. Methods: Participants were four groups of adolescents diagnosed with MDD ( Results: Suicidal ideators, irrespective of whether they had attempted suicide previously, had higher depression severity, higher anxiety and lower resilience compared to non-ideators. Hopelessness was associated with greater odds of being a suicidal ideator ( Limitations: Only cross-sectional data was included, and data was based mostly on self-report measures. Conclusions: Suicidal thoughts are associated with increases in hopelessness while suicide attempts are linked to non-suicidal self-harm behavior. Treatment of non-suicidal self-harm behavior might be an effective suicide prevention strategy in young people with depression. Clinical Trial Registration: www.ClinicalTrials.gov, identifier (NCT03167307).

Indexed as

adolescentschildrendepressionnon-suicidal self-injurysuicidal ideationsuicide attempts

Identifiers

PMID40061518
PMCPMC11885278

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.