ArticleJournal of asthma and allergy2025
Associations of Protein Classes With Cross-Reactivity and Cross-Sensitization in Furry Animal Allergens: A Component-Resolved Diagnostics Study.
Article in Journal of asthma and allergy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Occupational Allergy to Rat and Mouse in Research Laboratories.Current allergy and asthma reports · 2026Review
- Advance in Managing Indoor Cat Allergen Proteins: Molecular Insights, Detection, and Control.International journal of molecular sciences · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: This study aimed to investigate the molecular sensitization patterns of cats, dogs, and horses in patients with cat and/or dog sensitization and the IgE cross-reactivity with other furry animals. Methods: In 95 patients diagnosed with allergic diseases and sensitized to cats and/or dogs (confirmed by specific Immunoglobulin E (sIgE) ≥ 0.35 kU Results: Sensitization rates of crude extracts from other furry animals ranged from 16.8% to 49.5%. A strong positive correlation between cat and dog serum albumin (Fel d 2 and Can f 3) and rabbit epithelium, mouse epithelium, guinea pig epithelium and rat epithelium (rs: 0.66-0.87, all P < 0.05), while the lipocalin family (Fel d 4, Can f 1, Can f 2 and Equ c 1) only had a low to moderate correlation with the epithelial allergens of the above four animals (rs: 0.36-0.65, all P < 0.05). Simultaneous sensitization to SA and these four furry animal allergens accounted for 42.4%. sIgE levels of furry animal extracts were significantly higher in SA-positive groups (all P < 0.05) The results of the inhibition test showed that Fel d 2 and Can f 3 had high inhibition rates of four epithelial allergens, ranging from 66.5% to 91.8% and 75.8% to 91.9%, respectively. When lipocalin family components were used as inhibitors, the sIgE inhibition rates of these furry animal extracts were almost all lower than 50%. Conclusion: SA is the primary driver of cross-sensitization between cats, dogs, and other furry animals, rather than lipocalins.
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Registered trials
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