ArticleFrontiers in medicine2025
Association between accelerated biological aging and colorectal cancer: a cross-sectional study.
Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Biological aging, circulating lipid biomarkers and pancreatic diseases: a prospective cohort study based on the UK Biobank.The journal of nutrition, health & aging · 2026Article
- Evolution of the burden of disease for high BMI-associated colorectal cancer, 1990-2021: Global trends, regional heterogeneity, and population risk stratification.Preventive medicine reports · 2025Article
- Association of accelerated biological aging with kidney stone: Insights from the U.S. National health and nutrition examination survey.Preventive medicine reports · 2025Article
- The Association Between Accelerated Biological Aging as Measured by KDMAge and PhenoAge and Digestive System Cancer Risk: A Cross-Sectional Study Using NHANES Data (1999-2018).Journal of digestive diseasesArticle
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Biological age (BA) is regarded as a more accurate marker of aging than chronological age and is commonly used to assess associations with age-related diseases. The relationship between BA measures and the colorectal cancer (CRC) has not yet been investigated. Methods: This study utilized data from the National Health and Nutrition Examination Survey. BA was quantified using the Klemera-Doubal method age (KDMAge) and phenotypic age (PhenoAge), based on 13 common clinical biomarkers. The prevalence of CRC across quartiles of BA indicators was compared using weighted Chi-square tests. Weighted multivariable logistic regression models were used to assess the association between BA indicators and CRC. Results: A total of 36,684 participants were included. The weighted prevalence of CRC showed a significant and consistent upward trend across ascending quartiles of chronological age, KDMAge, and PhenoAge, even within gender and age subgroups (all Conclusion: Biological aging are positively associated with the prevalence of CRC regardless of gender, particularly among the elderly.
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