Status and Opportunities of Machine Learning Applications in Obstructive Sleep Apnea: A Narrative Review.

Background: Obstructive sleep apnea (OSA) is a prevalent and potentially severe sleep disorder characterized by repeated interruptions in breathing during sleep. Machine learning models have been increasingly applied in various aspects of OSA research, including diagnosis, treatment optimization, and developing biomarkers for endotypes and disease mechanisms. Objective: This narrative review evaluates the application of machine learning in OSA research, focusing on model performance, dataset characteristics, demographic representation, and validation strategies. We aim to identify trends and gaps to guide future research and improve clinical decision-making that leverages machine learning. Methods: This narrative review examines data extracted from 254 scientific publications published in the PubMed database between January 2018 and March 2023. Studies were categorized by machine learning applications, models, tasks, validation metrics, data sources, and demographics. Results: Our analysis revealed that most machine learning applications focused on OSA classification and diagnosis, utilizing various data sources such as polysomnography, electrocardiogram data, and wearable devices. We also found that study cohorts were predominantly overweight males, with an underrepresentation of women, younger obese adults, individuals over 60 years old, and diverse racial groups. Many studies had small sample sizes and limited use of robust model validation. Conclusion: Our findings highlight the need for more inclusive research approaches, starting with adequate data collection in terms of sample size and bias mitigation for better generalizability of machine learning models in OSA research. Addressing these demographic gaps and methodological opportunities is critical for ensuring more robust and equitable applications of artificial intelligence in healthcare.