Evidence map›Paper›PMID 40061336›Full record

ArticlemedRxiv : the preprint server for health sciences2025

Genetic Regulation of the Metabolome Differs by Sex, Alzheimer's Disease Stage, and Plasma Biomarker Status.

Jaclyn M Eissman, Min Qiao, Vrinda Kalia, Marielba Zerlin-Esteves, Dolly Reyes-Dumeyer, Angel Piriz, Saurabh Dubey, Renu Nandakumar, Annie J Lee, Rafael A Lantigua and 7 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors.

Jaclyn M EissmanTaub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, 10032, USA.ORCID 0000-0001-6439-3999
Min QiaoTaub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, 10032, USA.
Vrinda KaliaMailman School of Public Health, Columbia University, New York, NY, 10032, USA.
Marielba Zerlin-EstevesGertrude H. Sergievsky Center, Columbia University, New York, NY, 10032, USA.
Dolly Reyes-DumeyerTaub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, 10032, USA.
Angel PirizTaub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, 10032, USA.
Saurabh DubeyMailman School of Public Health, Columbia University, New York, NY, 10032, USA.
Renu NandakumarMailman School of Public Health, Columbia University, New York, NY, 10032, USA.
Annie J LeeTaub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, 10032, USA.
Rafael A LantiguaVagelos College of Physicians and Surgeons, Columbia University, New York, NY, 10032, USA.
Martin MedranoPontificia Universidad Católica Madre y Maestra, Santiago, Dominican Republic.
Diones Rivera MejiaCEDIMAT, Plaza de la Salud, Santo Domingo, Dominican Republic.
Lawrence S HonigTaub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, 10032, USA.ORCID 0000-0002-9703-2265
Clifton L DalgardPhysiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, 20814, USA.ORCID 0000-0003-2025-8239
Gary W MillerMailman School of Public Health, Columbia University, New York, NY, 10032, USA.
Richard MayeuxTaub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, 10032, USA.ORCID 0000-0001-6519-9696
Badri N VardarajanTaub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, 10032, USA.

Funding

Clinical and Translational Science AwardUL1TR001873 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI REILLY, MUREDACH P · 2016 to 2025
$99.0M
Genetic Epidemiology and Multi-Omics Analyses in Familial and Sporadic Alzheimer's Disease Among Secular Caribbean Hispanics and Religious OrderR01AG067501 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MAYEUX, RICHARD P, MILLER, GARY W · 2020 to 2024
$11.7M
Genetic Studies of Alzheimer's Disease in Caribbean HispanicsRF1AG015473 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MAYEUX, RICHARD P · 2015 to 2018
$3.3M
Genetic Epidemiology and Multi-Omics Analyses in Familial and Sporadic Alzheimer's Disease Among Secular Caribbean Hispanics and Religious OrdersR56AG063908 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MAYEUX, RICHARD P, MILLER, GARY W · 2019 to 2019
$2.3M
NCATS NIH HHS UL1 TR001873NIA NIH HHS R01 AG067501NIA NIH HHS R56 AG063908NIA NIH HHS RF1 AG015473
6 · The paper itself

Abstract

We investigated genetic regulators of circulating plasma metabolites to identify pathways underlying biochemical changes in clinical and biomarker-assisted diagnosis of Alzheimer's disease (AD). We computed metabolite quantitative trait loci by using whole genome sequencing and small molecule plasma metabolites from 229 older adults with clinical AD and 322 age-matched healthy controls. Unbiased associations between 6,881 metabolites and 332,772 common genetic variants were tested, adjusted for age, sex, and both metabolomic and genomic principal components. We identified 72 novel and known SNP-metabolite associations spanning 66 genes and 12 metabolite classes, including

Identifiers

PMID40061336
PMCPMC11888523

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.