ArticleFood science & nutrition2025
Unlocking the Potential of Freeze-Dried Broccoli Powder: A Novel Approach to Enhancing Cognitive Resilience in Temporal Lobe Epilepsy.
Article in Food science & nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cognitive impairment frequently accompanies temporal lobe epilepsy (TLE), which is linked to oxidative stress. Freeze-dried broccoli powder (BROC) exhibits diverse biological activities, particularly its antioxidant properties. Our study explored the effects of BROC on post-epileptic cognitive function. Male mice with lithium-pilocarpine-induced epilepsy were randomly divided into three groups: control group, model group (basal diet), and broccoli intervention group (basal diet supplemented with 4% BROC). Following 60 days of intervention, cognitive function was evaluated using IntelliCage Learning Tests, Novel Object Recognition, and Shuttle Box Tests. The hippocampal levels of malondialdehyde (MDA) and antioxidant enzyme activities were measured, and the protein expression levels of HO-1, NQO1, and Nrf2 were analyzed by Western blot. The results demonstrated that broccoli intervention significantly ameliorated cognitive deficits in epileptic mice, decreased hippocampal MDA levels while enhancing antioxidant enzyme activities, and upregulated the expression of HO-1, NQO1, and Nrf2. Consequently, BROC effectively attenuates OS and ameliorates cognitive deficits in TLE mice, suggesting its potential therapeutic value for post-epileptic cognitive dysfunction.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.