Evidence map›Paper›PMID 40061284›Full record

ArticleWorld journal of cardiology2025

Updates in breathomics behavior in ischemic heart disease and heart failure, mass-spectrometry.

Basheer Abdualah Marzoog, Peter Chomakhidze, Daria Gognieva, Alena Yurievna Parunova, Snezhana Nikolaevna Demchuk, Artemiy Silantyev, Natalia Kuznetsova, Anastasia Kostikova, Dmitrii Podgalo, Evgeny Nagornov and 2 more

Registry-linked trialAbstract read
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In one paragraph

Article in World journal of cardiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06181799 (Biomarkers of the Exhaled Breath and Single-Lead Electrocardiography in the Diagnosis of Myocardial Ischemia), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06181799 completednot on this map

Biomarkers of the Exhaled Breath and Single-Lead Electrocardiography in the Diagnosis of Myocardial Ischemia

TypeobservationalSponsorI.M. Sechenov First Moscow State Medical UniversityRan2023 to 2024Enrolled80ConditionsCoronary Artery Disease, Ischemic Heart Disease, Chronic Coronary Disease, Angina PectorisArmsMass spectrometry using the PTR TOF-1000 (IONICON PTR-TOF-MS - Trace VOC Analyzer, Eduard-Bodem-Gasse 3, 6020 Innsbruck, Austria (Europe).
3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Basheer Abdualah MarzoogDepartment of Cardiology, Sechenov University, Moscow 119991, Moskva, Russia. marzug@mail.ru.
Peter ChomakhidzeDepartment of Cardiology, Sechenov University, Moscow 119991, Moskva, Russia.
Daria GognievaDepartment of Cardiology, Sechenov University, Moscow 119991, Moskva, Russia.
Alena Yurievna ParunovaUndergraduate Student, National Research Ogarev Mordovia State University, Saransk 430005, Russia.
Snezhana Nikolaevna DemchukUndergraduate Student, Omsk State Medical University, Omsk 644099, Russia.
Artemiy SilantyevDepartment of Cardiology, Sechenov University, Moscow 119991, Moskva, Russia.
Natalia KuznetsovaDepartment of Cardiology, Sechenov University, Moscow 119991, Moskva, Russia.
Anastasia KostikovaUndergraduate Student, Sechenov University, Moscow 119991, Moskva, Russia.
Dmitrii PodgaloDepartment of Cardiology, Sechenov University, Moscow 119991, Moskva, Russia.
Evgeny NagornovDepartment of Cardiology, Sechenov University, Moscow 119991, Moskva, Russia.
Aida GadzhiakhmedovaDepartment of Cardiology, Sechenov University, Moscow 119991, Moskva, Russia.
Philipp KopylovDepartment of Cardiology, Sechenov University, Moscow 119991, Moskva, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCardiovascular disease (CVD) and associated sequalae remain the leading cause of disability worldwide. Ischemic heart disease (IHD) and heart failure are the most common etiologies of morbidity and mortality worldwide. This is due to the poor diagnostic and management methods for heart failure and IHD. Early detection of related risk factors through modern strategies is underestimated and requires further research.

aimTo interpret data from the published literature on volatile organic compounds (VOC), including all the methods used to analyze exhaled breath in patients with IHD and heart failure.

methodsSearches for specific keywords were performed on Scopus and PubMed. A total of 20 studies were identified in breath analysis and IHD and heart failure. The study is registered in PROSPERO (Registration No. CRD42023470556).

resultsConsidering the articles found, more research is required to gain a full understanding of the role of VOCs in IHD and heart failure. However, the existing literature demonstrates that cardiac metabolic changes can be expressed in exhaled air. The number of papers found is extremely low, making interpretation extremely difficult.

conclusionExhaled breath analysis can be a novel biomarker for the diagnosis and prevention of heart failure and IHD. Exhaled breath analysis can be used as a mirror to reflect the metabolic changes related to IHD and heart failure.

Indexed as

Angina pectorisArrythmiaIschemic heart diseaseMass spectrometrySystemic review

Identifiers

PMID40061284
PMCPMC11886397

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.