Evidence map›Paper›PMID 40061233›Full record

ArticlePeerJ2025

Effects of time, anticoagulant and detection channel on platelet count in ethylenediaminetetraacetic acid (EDTA)-dependent pseudothrombocytopenia.

Yu Zhang, Bei Chen, Jiaoying Feng, Wen Yu, Wei Liang, Meifen Li, Guanghua Zhai, Meina Yan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PeerJ, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yu Zhang *Department of Laboratory Medicine, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, Jiangsu, China.
Bei Chen *Department of Laboratory Medicine, The Affiliated Suzhou Hospital of Nanjing University Medical School, Suzhou, Jiangsu Province, China.
Jiaoying FengDepartment of Laboratory Medicine, Luoyang maternal and child health care hospital, Luoyang, Henan Province, China.
Wen YuDepartment of Laboratory Medicine, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, Jiangsu, China.
Wei LiangDepartment of Laboratory Medicine, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, Jiangsu, China.
Meifen LiDepartment of Laboratory Medicine, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, Jiangsu, China.
Guanghua ZhaiDepartment of Laboratory Medicine, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, Jiangsu, China.
Meina YanDepartment of Laboratory Medicine, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, Jiangsu, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: EDTA-dependent pseudothrombocytopenia (EDTA-PTCP) is an Methods: In this study, 43 identified EDTA-PTCP samples were collected. The Sysmex XN-9100, Mindray BC-6900 and Mindray BC-5390 haematology analysers were used to test these EDTA-PTCP samples on the following detection channels at different time points: PLT count by impedance method (PLT-I), PLT count by optical method (PLT-O) and PLT count by fluorescent staining (PLT-F). Results: EDTA-PTCP was time-dependent and small PLT agglutination occurred in most of the corresponding citrate-treated samples. Our results further demonstrated that the detection channel significantly affected the PLT count of the EDTA-PTCP samples. The XN-9100 PLT-F channel exhibited a greater dissociative effect than the XN-9100 PLT-I and PLT-O channels. Moreover, blood samples processed in the PLT-O channel of the Mindray hematology analyzer showed the highest PLT count in EDTA-K2 tubes compared to the other detection channels. Conclusion: Our data showed that time, anticoagulant and detection channel significantly affected the PLT count in the EDTA-PTCP samples. For the EDTA-PTCP samples, the simplest retest method was to use the PLT-O channel of the Mindray automatic blood analyser within 30 min. In addition, changing the sodium citrate anticoagulant and using the XN-9100 PLT-F channel within 15 min were also suitable for correcting the spurious low PLT of the EDTA-PTCP samples.

Indexed as

AnticoagulantsEdetic AcidThrombocytopeniaHumansPlatelet CountTime FactorsAnticoagulantsEdetic AcidDissociation effectEDTA-PTCPHaematology analyserPLT clumpsPLT physiology

Identifiers

PMID40061233
PMCPMC11887562

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.