ArticleObstetrics and gynecology research2025
In Utero Alcohol and Tobacco Exposure, Maternal Depression, And Maternal Obesity Are Associated with Impaired Oligodendrocyte Differentiation in The Developing Brain.
Article in Obstetrics and gynecology research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Maternal metformin treatment in obese pregnant dams normalizes neonatal sensory-motor reflexes.Molecular and cellular pediatrics · 2026Article
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Authors and funding
12 authors.
Funding
Abstract
Introduction: Fetal alcohol spectrum disorder (FASD) is the leading preventable cause of pediatric cognitive disability and is associated with dysmyelination. We examined possible clinical co-determinants that might interact with EtOH in impairing oligodendrocyte (OL) development. Women who drink, including pregnant women, also disproportionately suffer from depression (mDepression), which we have shown is a risk factor for FASD. Might depression during pregnancy contribute to OL pathology? Maternal obesity (mObesity) also inhibits white matter development in fetal brain. Finally, tobacco exposure inhibits not only OL development, but also the production of structural proteins, such as actin. Our human biobank derived from voluntarily terminated pregnancies allows us to study the effect of EtOH and tobacco exposure, mDepression and mObesity on OL markers. Methods: Fetal brain tissue (10 - 22 weeks) was collected and EtOH exposure estimated, based on a questionnaire adapted from the NIAAA PASS study. EtOH, tobacco, mObesity, mDepression exposed samples were compared with controls matched for gestational age and fetal gender. RNA expressions of OL markers were assayed by ddPCR. Fetal-brain-derived exosomes (FB-E) were isolated from maternal plasma. Exosomal RNA was studied for MBP, BDNF and actin mRNA expression by qRT-PCR and protein levels were confirmed by ELISA. Results: Forty-two subjects were used in EtOH, mObesity and mDepression studies, 40 cases were used in EtOH and tobacco studies, and 40 cases were used in OL-E (oligodendrocyte-derived exosomes) studies. Six cases were compared to 6 controls. EtOH exposure, mDepression and mObesity were associated with reduced mRNA expression of myelin basic Conclusions: Single Exposures to EtOH or tobacco, mObesity and mDepression all are associated with delayed OL maturation. When these exposures are combined the effects appear to be synergistic. Our unique biobank can be used to determine the mechanism(s) of specific adverse exposures and may suggest novel therapeutic or prophylactic interventions to lessen the severity of FASD.
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