Evidence map›Paper›PMID 40061205›Full record

ArticleLaryngoscope investigative otolaryngology2025

Mutations in Anaplastic Thyroid Carcinoma: An Analysis of the Japanese National Genomic Database.

Hiromi Nagano, Hayato Matsumoto, Yumi Ando, Masatoyo Nakajo, Masaru Yamashita

Abstract read
In one paragraph

Article in Laryngoscope investigative otolaryngology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Homologous Recombination in Thyroid Tumor Samples.International journal of molecular sciences · 2025
    Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Hiromi NaganoDepartment of Otolaryngology Head and Neck Surgery Kagoshima University Graduate School of Medical and Dental Sciences Kagoshima Japan.ORCID https://orcid.org/0000-0002-9080-7259
Hayato MatsumotoDepartment of Otolaryngology Head and Neck Surgery Kagoshima University Graduate School of Medical and Dental Sciences Kagoshima Japan.ORCID https://orcid.org/0009-0002-2562-7806
Yumi AndoDepartment of Otolaryngology Head and Neck Surgery Kagoshima University Graduate School of Medical and Dental Sciences Kagoshima Japan.ORCID https://orcid.org/0009-0004-8754-1252
Masatoyo NakajoDepartment of Otolaryngology Head and Neck Surgery Kagoshima University Graduate School of Medical and Dental Sciences Kagoshima Japan.ORCID https://orcid.org/0000-0001-9224-1730
Masaru YamashitaDepartment of Otolaryngology Head and Neck Surgery Kagoshima University Graduate School of Medical and Dental Sciences Kagoshima Japan.ORCID https://orcid.org/0000-0002-9861-1517

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: The purpose of this study is to investigate the genetic mutational status of anaplastic thyroid carcinoma (ATC) and its prognostic implications. Methods: Data were analyzed for 129 consecutive patients with ATC registered at the Japan National Cancer Center, Center for Cancer Genomics and Advanced Therapeutics (C-CAT) between June 2019 and June 2024. Genetic alterations were determined by FoundationOne CDx or Liquid CDx next-generation sequencing. The survival of patients was determined by the log-rank test and a Cox proportional hazards model. Results: The top 30 mutations in ATC were Conclusions: In ATC, Level of Evidence: 3.

Indexed as

anaplastic thyroid carcinomaBRCA2genetic mutationPIK3CASTK11

Identifiers

PMID40061205
PMCPMC11886988

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.