Evidence map›Paper›PMID 40061126›Full record

ArticleFrontiers in genetics2025

LINC00461 SNPs rs933647 and rs201864123 modify the risk of adenoid hypertrophy susceptibility for children in South China.

Chao Hou, Xilian Luo, Xin Wan, Kaining Chen, Zhongren Xian, Kaixiong Xu, Yingjia Zeng, Chenlu Wang, Wan Yang, Zilin Zheng and 5 more

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Article in Frontiers in genetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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15 authors.

Chao Hou *Department of Otolaryngology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, Guangdong, China.
Xilian Luo *Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Department of Clinical Biological Resource Bank, Guangzhou Women and Children's Medical Center, Guangzhou Institute of Pediatrics, Guangzhou Medical University, Guangzhou, China.
Xin Wan *Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Department of Clinical Biological Resource Bank, Guangzhou Women and Children's Medical Center, Guangzhou Institute of Pediatrics, Guangzhou Medical University, Guangzhou, China.
Kaining ChenGuangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Department of Clinical Biological Resource Bank, Guangzhou Women and Children's Medical Center, Guangzhou Institute of Pediatrics, Guangzhou Medical University, Guangzhou, China.
Zhongren XianMedicine Inspection Department of the Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.
Kaixiong XuDepartment of Laboratory Medicine, The Second Affiliated Hospital, School of Medicine, South China University of Technology, Guangzhou, China.
Yingjia ZengSchool of Clinical Medicine, Kunming Medical University, Kunming, Yunnan, China.
Chenlu WangGuangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Department of Clinical Biological Resource Bank, Guangzhou Women and Children's Medical Center, Guangzhou Institute of Pediatrics, Guangzhou Medical University, Guangzhou, China.
Wan YangGuangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Department of Clinical Biological Resource Bank, Guangzhou Women and Children's Medical Center, Guangzhou Institute of Pediatrics, Guangzhou Medical University, Guangzhou, China.
Zilin ZhengGuangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Department of Clinical Biological Resource Bank, Guangzhou Women and Children's Medical Center, Guangzhou Institute of Pediatrics, Guangzhou Medical University, Guangzhou, China.
Yueling LinGuangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Department of Clinical Biological Resource Bank, Guangzhou Women and Children's Medical Center, Guangzhou Institute of Pediatrics, Guangzhou Medical University, Guangzhou, China.
Zhaojin LuGuangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Department of Clinical Biological Resource Bank, Guangzhou Women and Children's Medical Center, Guangzhou Institute of Pediatrics, Guangzhou Medical University, Guangzhou, China.
Yanqiu ChenDepartment of Otolaryngology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, Guangdong, China.
Di CheGuangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Department of Clinical Biological Resource Bank, Guangzhou Women and Children's Medical Center, Guangzhou Institute of Pediatrics, Guangzhou Medical University, Guangzhou, China.
Xiaoqiong GuGuangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Department of Clinical Biological Resource Bank, Guangzhou Women and Children's Medical Center, Guangzhou Institute of Pediatrics, Guangzhou Medical University, Guangzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Adenoidal hypertrophy (AH) is commonly observed in childhood and closely linked to obstructive sleep apnea (OSA). Despite the high prevalence of AH, its pathophysiological mechanisms remain incompletely understood. We attempt to explore this issue from a genetic perspective. Elevated levels of LINC00461 have been identified in OSA tissues. We aimed to explore the relationship between susceptibility to adenoid hypertrophy and LINC00461 gene polymorphisms. Methods: We genotyped the LINC00461 single nucleotide polymorphisms (SNPs) rs933647 and rs201864123 in 546 AH patients and 574 healthy controls. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to assess the association between the SNPs and AH risk. The SIPI (Susceptible-Infected-Protected-Infected) method was utilized to analyze SNP-SNP interactions between rs933647 and rs201864123. Results: Our study found that the rs933647 GA polymorphism was associated with an increased risk of AH. Similarly, the T allele of SNP rs201864123 increased AH risk in southern Chinese children. Furthermore, SIPI analysis demonstrated an interaction between these SNPs associated with adenoid hypertrophy risk. Conclusion: The LINC00461 rs933647 GA genotype and rs201864123 T variant may contribute to the susceptibility of AH in the child population of China.

Indexed as

adenoidal hypertrophyLINC00461microRNASNPsusceptibility

Identifiers

PMID40061126
PMCPMC11885279

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