ReviewClinical, cosmetic and investigational dermatology2025
Progress in the Application of Molecular Hydrogen in Medical Skin Cosmetology.
Review in Clinical, cosmetic and investigational dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Bioactive Potential ofPlants (Basel, Switzerland) · 2025Article
- Topically Applied Molecular Hydrogen Normalizes Skin Parameters Associated with Oxidative Stress: A Pilot Study.Antioxidants (Basel, Switzerland) · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Molecular hydrogen is a colorless, tasteless, biologically active small-molecule gas with reducing properties, demonstrating therapeutic and preventive effects across various human systems. Its mechanisms of action include selective antioxidation, anti-inflammatory effects, apoptosis inhibition, and the regulation of gene expression and signaling pathways. In the skin, molecular hydrogen reduces oxidative damage by scavenging free radicals and inhibiting oxidative stress, leading to improvements in texture and tone. It also regulates the inflammatory response, alleviating redness, itching, and discomfort, while promoting skin repair and regeneration. Moreover, hydrogen activates antioxidant enzymes in skin cells, boosting their antioxidant capacity and delaying aging. Clinical trials show that molecular hydrogen significantly improves conditions like acne, chloasma, and skin sensitivity. However, research in skin cosmetology remains in its early stages, with unanswered questions regarding mechanisms of action, optimal dosage, and long-term safety. Further investigation through clinical trials is essential for expanding its applications in this field. Molecular hydrogen holds significant promise in skin cosmetology, and as research and technology evolve, it is expected to drive innovations and breakthroughs in skin care. This review examines the therapeutic potential, mechanisms, and clinical applications of molecular hydrogen in skin cosmetology, addressing challenges and proposing pathways for future advancements in this field.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.