Evidence map›Paper›PMID 40060986›Full record

ArticleCrystal growth & design2025

Revealing the Crystal Structure of the Purine Base Xanthine with Three-Dimensional (3D) Electron Diffraction.

Helen W Leung, Royston C B Copley, Giulio I Lampronti, Sarah J Day, Lucy K Saunders, Duncan N Johnstone, Paul A Midgley

Abstract read
In one paragraph

Article in Crystal growth & design, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Discovery of a new zinc oxide semiconductor: 21R polytype.Structural dynamics (Melville, N.Y.) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Helen W LeungDepartment of Materials Science and Metallurgy, University of Cambridge, 27 Charles Babbage Road, Cambridge, CB3 0FS, United Kingdom.ORCID https://orcid.org/0000-0002-5434-8673
Royston C B CopleyGSK R&D, Gunnels Wood Road, Stevenage, SG1 2NY, United Kingdom.
Giulio I LamprontiDepartment of Materials Science and Metallurgy, University of Cambridge, 27 Charles Babbage Road, Cambridge, CB3 0FS, United Kingdom.ORCID https://orcid.org/0000-0002-1430-3446
Sarah J DayDiamond Light Source, Ltd., Beamline I11, Harwell, Oxford, OX11 0DE, United Kingdom.
Lucy K SaundersDiamond Light Source, Ltd., Beamline I11, Harwell, Oxford, OX11 0DE, United Kingdom.ORCID https://orcid.org/0000-0001-5689-8129
Duncan N JohnstoneGSK R&D, Gunnels Wood Road, Stevenage, SG1 2NY, United Kingdom.ORCID https://orcid.org/0000-0003-3663-3793
Paul A MidgleyDepartment of Materials Science and Metallurgy, University of Cambridge, 27 Charles Babbage Road, Cambridge, CB3 0FS, United Kingdom.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Three-dimensional (3D) electron diffraction (3D-ED) techniques can be used for structure determination, circumventing challenges posed to conventional and bulk X-ray diffraction techniques such as submicrometer-sized crystals, the strong effects of texture, the presence of defects, and polyphasic samples. Such challenges previously prevented the structure solution of xanthine, a purine base chemically similar to guanine that may also be found in organisms. In this work, we use 3D-ED to elucidate the crystal structure of xanthine. The electron diffraction data obtained from a single microcrystal is also of sufficient quality to determine hydrogen positions, confirming the presence of the 7

Identifiers

PMID40060986
PMCPMC11887060

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.