Evidence map›Paper›PMID 40060907›Full record

ArticleiScience2025

Episodic rhythmicity is generated by a distributed neural network in the developing mammalian spinal cord.

Jonathan J Milla-Cruz, Adam P Lognon, Michelle A Tran, Stephanie A Di Vito, Carlotta Löer, Anchita Shonak, Matthew J Broadhead, Gareth B Miles, Simon A Sharples, Patrick J Whelan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jonathan J Milla-CruzHotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada.
Adam P LognonHotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada.
Michelle A TranHotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada.
Stephanie A Di VitoHotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada.
Carlotta LöerSchool of Psychology and Neuroscience, University of St Andrews, Fife KY16 9JP, UK.
Anchita ShonakHotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada.
Matthew J BroadheadSchool of Psychology and Neuroscience, University of St Andrews, Fife KY16 9JP, UK.
Gareth B MilesSchool of Psychology and Neuroscience, University of St Andrews, Fife KY16 9JP, UK.
Simon A SharplesDivision of Neurosurgery, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Patrick J WhelanHotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Spinal circuits generate locomotor rhythms, but the mechanisms behind episodic locomotor behaviors remain unclear. This study investigated dopamine-induced episodic rhythms in isolated neonatal mouse spinal cords to understand these mechanisms. The episodic rhythms were generally synchronous and propagated rostro-caudally, although occasional asynchrony was observed. Electrical stimulation of the L5 dorsal root entrained the episodic rhythms, suggesting afferent control and a distributed network. Even after transection or ventrolateral funiculus (VLF) lesions, episodic activity persisted in isolated thoracic or sacral segments, implying VLF-coupled networks. Rhythmicity was observed in VLF and dorsal root axons and was independent of cholinergic excitation via motoneurons, GABA

Indexed as

Molecular neuroscienceNeuroscienceSensory neuroscience

Identifiers

PMID40060907
PMCPMC11889695

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.