ArticleACS omega2025
Exposure of Human Nasal Epithelial Cells to Polycyclic Aromatic Hydrocarbons Differentially Increases Markers of Inflammation and Expression of Aryl Hydrocarbon Pathway Genes.
Article in ACS omega, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Protective Effects of Shallot (International journal of molecular sciences · 2026Article
- Wildland-Urban Interface Fires: Toxic Physicochemical Properties of Emitted Particulate Matter and Impacts on Lung Macrophages.Environmental science & technology · 2026Article
- Impact of nanoplastics emitted from incineration of polyethylene plastic on THP-1 macrophage viability and immune function.Journal of hazardous materials · 2026Article
- Development and characterization of reference environmentally relevant micro-nano-plastics for risk assessment studies.NanoImpact · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Inhalation of polycyclic aromatic hydrocarbons (PAHs) derived from emissions of solid waste combustion is of public health concern, as PAHs are associated with respiratory cancers and inflammatory diseases. Here, we chose seven individual PAHs associated with gene expression changes induced by exposure to plastic incineration emission mixtures in human nasal epithelial cells in vitro and further elucidated inflammatory cytokine release and expression of aryl hydrocarbon (AhR) pathway gene response by these PAHs and ranked their toxicities. Overall ranking analyses showed differential inflammatory and gene expression potentials among PAHs, with high-molecular-weight PAHs inducing responses greater than those of their low-molecular-weight counterparts. Observed findings causally link PAHs contained in combustion mixtures with biological responses and highlight the importance of understanding chemical profiles in combustion emissions to properly estimate the human respiratory hazard potentials.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.