Evidence map›Paper›PMID 40060854›Full record

ArticleACS omega2025

Enhanced Cartilage Regeneration: Chemical, Mechanical, and In Vitro Analysis of Innovative TiO

Santosh Kumar B Y, Arun M Isloor, G C Mohan Kumar, Srirangam Prashanth, Anoop Penupolu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS omega, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Santosh Kumar B YSironix Division-Research & Development, Arthroscopy & Sports Medicine, Healthium Medtech, Bangalore560058, India.
Arun M IsloorMedicinal Chemistry Laboratory, Department of Chemistry, National Institute of Technology Karnataka, Surathkal, Mangalore 575 025, India.ORCID https://orcid.org/0000-0003-2038-3494
G C Mohan KumarPolymer Composites Laboratory, Department of Mechanical Engineering, National Institute of Technology Karnataka, Surathkal, Mangalore 575 025, India.
Srirangam PrashanthQuality Assurance and Toxicology, Healthium Medtech, Bangalore 560058, India.
Anoop PenupoluSironix Division-Research & Development, Arthroscopy & Sports Medicine, Healthium Medtech, Bangalore560058, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study focuses on developing a synthetic, biocompatible graft for treating cartilage lesions. One-dimensional titanium dioxide nanotubes (TNTs) were incorporated into poly(vinyl alcohol) (PVA) hydrogel and processed using freeze-drying without chemical surfactants. Upon optimization of the composition, it was found that the incorporation of TNT altered the biomechanical properties without causing any adverse physiological effects. Annealing treatment further enhanced mechanical strength and energy dissipation, promoting elasticity. The hydrogel with 2 wt % TNT achieved maximum mechanical strength and the storage modulus values indicated elastic dominance, and biotribological tests showed cartilage-like frictional response via hydrodynamic lubrication. Against the microorganisms

Identifiers

PMID40060854
PMCPMC11886706

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.