ArticleACS omega2025
Novel Thermosensitive Hydrogel Encapsulated Carvedilol for the Treatment of Rosacea.
Article in ACS omega, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Design and Optimization of Thermosensitive Hydrogels Combined with Lipid Nanotechnology for Topical Curcumin Application.Gels (Basel, Switzerland) · 2026Article
- Therapeutic progress in rosacea: targeting the neuro-vascular-immune triad.Frontiers in immunology · 2026Review
- Injectable thermosensitive hydrogel co-loading with ATRi and doxorubicin for the treatment of triple-negative breast cancer.RSC advances · 2025Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCarvedilol can be used in the treatment of rosacea. However, their oral administration often results in a series of adverse effects. PURPOSE: A novel thermosensitive hydrogel was developed to improve the administration of carvedilol in the treatment of rosacea and to evaluate its safety and efficacy.
methodsThe thermosensitive hydrogel was formulated using varying ratios of poloxamer 407 (P407) and poloxamer 188 (P188), with carvedilol being encapsulated during the process. The gel temperature and time of the hydrogel were observed, its phase transition was assessed through the inverted tube test, its microstructure was examined using scanning electron microscopy (SEM), and its characteristic functional groups were identified with Fourier transform infrared spectrometry (FTIR). The hydrogel's therapeutic efficacy on a rosacea-like phenotype in mice was evaluated through in vitro experiments.
resultsIt is observed that the microstructure of the hydrogel possesses a porous structure, with pores uniformly arranged in a square lattice measuring 8-12 μm in diameter. Thermosensitive hydrogel encapsulated carvedilol (Car-P407
conclusionCar-P407
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Registered trials
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