ArticleACS omega2025
Dual Cross-Linked Chitosan-Based Films with pH-Sensitive Coloration and Drug Release Kinetics for Smart Wound Dressings.
Article in ACS omega, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The trial behind it
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Who cites it
3 citing papers in PubMed.
- Multifunctional Silk Fibroin-Curcuminoid Films Combining Regenerative and Antioxidant Properties with pH Sensing for Wound Dressing Applications.Biomimetics (Basel, Switzerland) · 2026Article
- Development of Resveratrol/Curcumin Dual-Loaded Chitosan/Sericin Hydrogel Films for Wound Healing: A Comparison Of Shrimp- and Crab-Sourced Chitosan.AAPS PharmSciTech · 2026Article
- Development of Smart pH-Sensitive Collagen-Hydroxyethylcellulose Films with Naproxen for Burn Wound Healing.Pharmaceuticals (Basel, Switzerland) · 2025Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this study, we developed dual-cross-linked hydrogel films based on carboxyethyl chitosan (CECS) and sodium alginate (SA), utilizing dialdehyde β-cyclodextrin (DA-βCD) and gluconic acid δ-lactone (GDL) as cross-linkers. Designed as smart wound dressings, the films exhibit pH sensitivity due to the incorporation of carboxyethylated phenol red-grafted chitosan (CS-PR-AA), which allows them to change color from orange to purple in response to pH variations. FT-IR and TGA analyses confirmed the formation of imine bonds and polyelectrolyte complexes, indicating successful cross-linking. The films demonstrated high cell viability, confirming their biocompatibility and nontoxicity. The swelling behavior varied with pH, underscoring their adaptability to different wound environments. Additionally, drug release kinetics were studied for films incorporating diclofenac sodium (DCF) at various pH levels, revealing that the release rate was influenced by cross-linking density and environmental pH. These findings suggest that the dual-cross-linked hydrogel films have significant potential as smart wound dressings, offering controlled drug release and pH-responsive behavior suitable for wound care applications.
Identifiers
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Registered trials
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