Evidence map›Paper›PMID 40060799›Full record

ArticleACS omega2025

Site-Selective Approaches to Attain Fluorescent Human Insulin Conjugates: Balancing the Site of Labeling and the

Bayan Alkhawaja, Ghayda' AlDabet, Nour Alkhawaja, Bayan Y Ghanim, Khaled Al-Khatib, Shaun Reeksting, Andreas Michael, Duaa Abuarqoub, Marwa Mohammad, Andrew G Watts and 1 more

Abstract read
In one paragraph

Article in ACS omega, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Bayan AlkhawajaFaculty of Pharmacy and Medical Sciences, University of Petra, Amman 11196, Jordan.ORCID https://orcid.org/0000-0002-1547-3906
Ghayda' AlDabetUniversity of Petra Pharmaceutical Center, Faculty of Pharmacy and Medical Sciences, Petra University, Amman 11196, Jordan.
Nour AlkhawajaFaculty of Pharmacy and Medical Sciences, University of Petra, Amman 11196, Jordan.
Bayan Y GhanimUniversity of Petra Pharmaceutical Center, Faculty of Pharmacy and Medical Sciences, Petra University, Amman 11196, Jordan.
Khaled Al-KhatibUniversity of Petra Pharmaceutical Center, Faculty of Pharmacy and Medical Sciences, Petra University, Amman 11196, Jordan.
Shaun ReekstingAgilent Technologies U.K. Ltd., Lakeside, Cheadle Royal Business Park, Stockport, SK8 3GR Cheshire, U.K.
Andreas MichaelDepartment of Life Sciences, University of Bath, Claverton Down, BA2 7AY Bath, U.K.
Duaa AbuarqoubFaculty of Pharmacy and Medical Sciences, University of Petra, Amman 11196, Jordan.
Marwa MohammadFaculty of Pharmacy and Medical Sciences, University of Petra, Amman 11196, Jordan.
Andrew G WattsDepartment of Life Sciences, University of Bath, Claverton Down, BA2 7AY Bath, U.K.
Nidal A QinnaUniversity of Petra Pharmaceutical Center, Faculty of Pharmacy and Medical Sciences, Petra University, Amman 11196, Jordan.ORCID https://orcid.org/0000-0002-9628-6036

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fluorescent insulin is commonly used for a range of detection and imaging purposes. Achieving site-selective insulin labeling affords superior labeling yield while retaining its biological activity. Insulin labeling is usually achieved using commercial kits with minimal emphasis on the site and degree of labeling. To bridge this gap, this work highlights the essential parameters concerning the development of fluorescent insulin and reflects them on the biological activity of insulin

Identifiers

PMID40060799
PMCPMC11886657

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.