ArticleFrontiers in psychiatry2025
Abnormal static and dynamic functional connectivity of striatal subregions in patients with obsessive-compulsive disorder.
Article in Frontiers in psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
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Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Mapping research trends in obsessive-compulsive disorder before and after the COVID-19 pandemic: a bibliometric analysis focusing on its molecular mechanisms.Frontiers in psychiatry · 2025Pooled it
- Altered seed-to-whole-brain functional connectivity of goal-directed/habitual systems in obsessive-compulsive disorder: associated genes and preliminary classification potential.European archives of psychiatry and clinical neuroscience · 2026Article
- Neural mechanisms underlying cognitive inflexibility in obsessive-compulsive disorder: a review.Frontiers in psychiatry · 2026Review
- Sequential rTMS for MDD and OCD in a patient with left parietal perinatal ischemic infarct: a case report.Frontiers in psychiatry · 2026Article
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: As a crucial node of the cortico-striato-thalamo-cortical (CSTC) loop, the striatum has long been considered to be involved in the pathophysiology of obsessive-compulsive disorder (OCD). Numerous neuroimaging studies have reported functional abnormalities of the striatum in OCD. However, altered dynamic functional connectivity (DFC) patterns of striatal subregions were rarely reported in patients with OCD. Methods: We collected resting-state functional MRI data from 97 first episode and drug-naïve OCD patients and 106 HCs matched for gender and age. Seed-based whole-brain resting-state functional connectivity (RSFC) and DFC analysis were performed for 12 striatal subregions. Between-group differences of the mean RSFC and DFC were determined using a two-sample t-test. In addition, we performed a Spearman's correlation analysis to examine the relationship between altered RSFC and DFC and the clinical characteristics of OCD. Results: Patients with OCD exhibited increased RSFC between the superior ventral striatum (VSs) and the calcarine (CAL), lingual gyrus (LING), cuneus (CUN), supplementary motor area (SMA), precuneus (PCUN), paracentral lobule (PCL) and superior parietal gyrus (SPG). Increased RSFC between the left dorsal caudal putamen (DCP) and LING and inferior occipital gyrus (IOG) and increased RSFC between left ventral rostral putamen (VRP) and fusiform gyrus (FFG) were also found. in OCD group. The left dorsal caudate (DC) showed increased RSFC with CAL. In addition, OCD patients shows increased RSFC between multiple striatal seeds and cerebellum. The left VSs showed decreased DFC in the OCD patients with the PCUN, SPG and superior occipital gyrus (SOG). The right DC showed decreased DFC with the medial frontal gyrus orbital part (ORBmed), superior frontal gyrus orbital part (ORBsup) and gyrus rectus (REC). OCD severity was associated with DFC values between the right DC and ORBmed (r = 0.209, p = 0.044). Conclusion: Our study reveals disrupted RSFC and DFC between the striatal subregions and widespread brain regions in OCD patients. The findings highlight the role of the striatum in the neuropathology of OCD at a refined anatomical level and support the CSTC model in OCD.
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