Evidence map›Paper›PMID 40060700›Full record

ArticlebioRxiv : the preprint server for biology2025

Activity of human-specific Interlaminar Astrocytes in a Chimeric Mouse Model of Fragile X Syndrome.

Alexandria Anding, Baiyan Ren, Ragunathan Padmashri, Maria Burkovetskaya, Anna Dunaevsky

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Alexandria AndingDepartment of Genetics Cell Biology and Anatomy, University of Nebraska Medical Center.
Baiyan RenDepartment of Biochemistry and Molecular Biology, University of Nebraska Medical Center.
Ragunathan PadmashriDepartment of Neurological Sciences, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Maria BurkovetskayaDepartment of Neurological Sciences, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Anna DunaevskyDepartment of Neurological Sciences, University of Nebraska Medical Center, Omaha, NE 68198, USA.

Funding

Developing an Astroglial Model for Fragile X SyndromeR21NS122157 · NINDS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI DUNAEVSKY, ANNA · 2021 to 2021
$434k
NINDS NIH HHS R21 NS122157
6 · The paper itself

Abstract

Astrocytes, a subtype of glial cells, have multiple roles in regulating neuronal development and homeostasis. In addition to the typical mammalian astrocytes, in the primate cortex interlaminar astrocytes are located in the superficial layer and project long processes traversing multiple layers of the cerebral cortex. Previously, we described a human stem cell based chimeric mouse model where interlaminar astrocytes develop. Here, we utilized this model to study the calcium signaling properties of interlaminar astrocytes. To determine how interlaminar astrocytes could contribute to neurodevelopmental disorders, we generated a chimeric mouse model for Fragile X syndrome. We report that FXS interlaminar astrocytes exhibit hyperexcitable calcium signaling and are associated with dendritic spines with increased turnover rate.

Indexed as

astrocytesCalciumcortexdendritic spinesinterlaminariPSCprimate

Identifiers

PMID40060700
PMCPMC11888414

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.