ArticlebioRxiv : the preprint server for biology2025
PepCentric Enables Fast Repository-Scale Proteogenomics Searches.
Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
4 authors.
Funding
Abstract
Identifying novel peptides arising from alternative splicing, mutations, or non-canonical translations is a crucial yet challenging aspect of proteogenomics. We introduce PepCentric, a scalable computational platform and a web-based portal utilizing advanced 2-D fragment indexing for rapid peptide-centric searches across extensive mass spectrometry datasets. With robust false discovery rate control and optimized search performance, PepCentric offers an efficient tool for validating novel peptides and exploring proteomic variations. In a matter of seconds, users can search their novel peptides or proteins against 2.3 billion spectra collected from 66700 mass spectrometry runs, making it practical to rapidly validate proteogenomic hypotheses.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.