Evidence map›Paper›PMID 40060676›Full record

ArticlebioRxiv : the preprint server for biology2025

Identification of chemical features that influence mycomembrane permeation and antitubercular activity.

Irene Lepori, Zichen Liu, Nelson Evbarunegbe, Shasha Feng, Turner P Brown, Kishor Mane, Shivangi, Mitchell Wong, Amir George, Taijie Guo and 6 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Irene LeporiDepartment of Microbiology, University of Massachusetts, Amherst; Amherst, MA, USA.ORCID 0000-0002-1602-0490
Zichen LiuDepartment of Chemistry, University of Virginia; Charlottesville, VA, USA.
Nelson EvbarunegbeManning College of Information and Computer Sciences, University of Massachusetts, Amherst; Amherst, MA, USA.
Shasha FengDepartment of Biological Sciences, Lehigh University; Bethlehem, PA, USA.
Turner P BrownDepartment of Biological Sciences, Lehigh University; Bethlehem, PA, USA.
Kishor ManeDepartment of Pharmacology, Physiology and Neuroscience, Rutgers University-New Jersey Medical School; Newark, NJ, USA.
ShivangiDepartment of Pharmacology, Physiology and Neuroscience, Rutgers University-New Jersey Medical School; Newark, NJ, USA.
Mitchell WongDepartment of Microbiology, University of Massachusetts, Amherst; Amherst, MA, USA.
Amir GeorgeDepartment of Pharmacology, Physiology and Neuroscience, Rutgers University-New Jersey Medical School; Newark, NJ, USA.
Taijie GuoInstitute of Translational Medicine, Zhangjiang Institute for Advanced Study, Shanghai Jiao Tong University; Shanghai, China.
Jiajia DongInstitute of Translational Medicine, Zhangjiang Institute for Advanced Study, Shanghai Jiao Tong University; Shanghai, China.
Joel S FreundlichDepartment of Pharmacology, Physiology and Neuroscience, Rutgers University-New Jersey Medical School; Newark, NJ, USA.
Wonpil ImDepartment of Biological Sciences, Lehigh University; Bethlehem, PA, USA.
Anna G GreenManning College of Information and Computer Sciences, University of Massachusetts, Amherst; Amherst, MA, USA.
Marcos M PiresDepartment of Chemistry, University of Virginia; Charlottesville, VA, USA.
M Sloan SiegristDepartment of Microbiology, University of Massachusetts, Amherst; Amherst, MA, USA.ORCID 0000-0002-8232-3246

Funding

Therapeutics for drug-resistant bacteria: aryl myxopyronins and arylalkylcarboxamido phloroglucinolsU19AI142731 · NIAID · HACKENSACK UNIVERSITY MEDICAL CENTER · PI PERLIN, DAVID S · 2019 to 2023
$33.9M
Unraveling Bacterial Cell Wall Biosynthesis and Sensing via Synthetic AnalogsR35GM124893 · NIGMS · UNIVERSITY OF VIRGINIA · PI Marcos M. Pires · 2017 to 2026
$3.6M
A Preclinical Program for Targeting Mycobacterium tuberculosis KasAR01AI153145 · NIAID · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI FREUNDLICH, JOEL STEPHEN · 2021 to 2024
$3.2M
Bacterial and Molecular Determinants of Mycobacterial ImpermeabilityR01AI179080 · NIAID · UNIVERSITY OF VIRGINIA · PI Marcos M. Pires, Mary Sloan Siegrist · 2023 to 2026
$2.9M
NIAID NIH HHS R01 AI153145NIAID NIH HHS R01 AI179080NIAID NIH HHS U19 AI142731NIGMS NIH HHS R35 GM124893
6 · The paper itself

Abstract

Tuberculosis (TB), caused by

Indexed as

bioorthogonal click chemistrymachine learningmycomembranepermeabilitytuberculosis

Identifiers

PMID40060676
PMCPMC11888444

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.