Evidence map›Paper›PMID 40060674›Full record

ArticlebioRxiv : the preprint server for biology2025

Exploiting the Angiotensin-Converting Enzyme Pathway to Augment Endogenous Opioid Signaling.

Prakashkumar Dobariya, Jessica Williams, Filip Hanak, Patrick E Rothwell, Swati S More

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Prakashkumar Dobariya
Jessica Williams
Filip Hanak
Patrick E Rothwell
Swati S More

Funding

Identification of small molecules that regulate endogenous opioid signaling by inhibiting angiotensin converting enzymeR01DA056331 · NIDA · UNIVERSITY OF MINNESOTA · PI Swati S More, Patrick Rothwell · 2022 to 2026
$2.9M
NIDA NIH HHS R01 DA056331
6 · The paper itself

Abstract

Angiotensin Converting Enzyme (ACE) impacts hemodynamics by regulating the conversion of angiotensin I to the vasoconstricting angiotensin II. We recently identified

Identifiers

PMID40060674
PMCPMC11888239

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.