Evidence map›Paper›PMID 40060670›Full record

ArticlebioRxiv : the preprint server for biology2025

Activation and Evasion of the FEAR Pathway by RNA Viruses.

Emily A Rex, Dahee Seo, Aaron Embry, Rozanne Arulanandam, Marcus M Spinelli, Jean-Simon Diallo, Don B Gammon

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Emily A RexDepartment of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.
Dahee SeoDepartment of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.
Aaron EmbryDepartment of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.
Rozanne ArulanandamCenter for Innovative Cancer Research, Ottawa Hospital Research Institute, 501 Smyth Road, Ottawa, Ontario K1H 8L6, Canada.
Marcus M SpinelliCenter for Innovative Cancer Research, Ottawa Hospital Research Institute, 501 Smyth Road, Ottawa, Ontario K1H 8L6, Canada.
Jean-Simon DialloCenter for Innovative Cancer Research, Ottawa Hospital Research Institute, 501 Smyth Road, Ottawa, Ontario K1H 8L6, Canada.
Don B GammonDepartment of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.ORCID 0000-0003-1144-4152

Funding

MOLECULAR MICROBIOLOGY TRAINING GRANTT32AI007520 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI Julie K Pfeiffer · 1997 to 2026
$7.0M
Exploiting Pathogen-Encoded Immune Evasion Proteins to Uncover Evolutionarily Conserved Antiviral Host MachineryR35GM137978 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI Don Brad Gammon · 2020 to 2026
$2.5M
Characterization of a Novel FACT-ETS-1 Antiviral Response Pathway and Identification of RNA Virus-Encoded Antagonists of this Host ResponseR21AI180551 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI GAMMON, DON BRAD · 2024 to 2025
$445k
NIAID NIH HHS R21 AI180551NIAID NIH HHS T32 AI007520NIGMS NIH HHS R35 GM137978
6 · The paper itself

Abstract

We recently identified the FACT-ETS-1 Antiviral Response (FEAR) pathway as an interferon-independent innate immune response that restricts DNA virus replication and is countered by poxvirus-encoded A51R proteins (Rex

Indexed as

ETS-1FACT complexFEAR pathwayRNA virusviral immune evasion

Identifiers

PMID40060670
PMCPMC11888236

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.